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β-defensin 1 expression in HCV infected liver/liver cancer: An important role in protecting HCV progression and liver cancer development
Ling Y.-M.6; Chen J.-Y.1; Guo L.2; Wang C.-Y.3; Tan W.-T.6; Wen Q.4; Zhang S.-D.5; Deng G.-H.6; Lin Y.3; Kwok H.F.2
2017-12-01
Source PublicationScientific Reports
ISSN20452322
Volume7Issue:1
Abstract

β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other β-defensin tested, with the extent and duration of upregulation associated with treatment response. We investigated β-defensin family expression in liver cancer in publicly available datasets and found that among all the β-defensins tested, only β-defensin 1 was significantly downregulated, suggesting β-defensin 1 plays a crucial role in liver cancer development. Further analysis identified E-cadherin as the top positive correlated gene, while hepatocyte growth factor-regulated tyrosine kinase substrate as the top negative correlated gene. Expression of two proteoglycans were also positively correlated with that of β-defensin 1. We have also identified small molecules as potential therapeutic agents to reverse β-defensin 1-associated gene signature. Furthermore, the downregulation of β-defensin 1 and E-cadherin, and upregulation of hepatocyte growth factor-regulated tyrosine kinase substrate, were further confirmed in liver cancer and adjacent normal tissue collected from in-house Chinese liver cancer patients. Together, our results suggest β-defensin 1 plays an important role in protecting HCV progression and liver cancer development.

DOIhttp://doi.org/10.1038/s41598-017-13332-0
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000413084800101
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The 180th Hospital of PLA
2.Universidade de Macau
3.Fujian Normal University
4.Queen's University Belfast
5.Ulster University
6.Third Military Medical University
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GB/T 7714
Ling Y.-M.,Chen J.-Y.,Guo L.,et al. β-defensin 1 expression in HCV infected liver/liver cancer: An important role in protecting HCV progression and liver cancer development[J]. Scientific Reports,2017,7(1).
APA Ling Y.-M..,Chen J.-Y..,Guo L..,Wang C.-Y..,Tan W.-T..,...&Kwok H.F..(2017).β-defensin 1 expression in HCV infected liver/liver cancer: An important role in protecting HCV progression and liver cancer development.Scientific Reports,7(1).
MLA Ling Y.-M.,et al."β-defensin 1 expression in HCV infected liver/liver cancer: An important role in protecting HCV progression and liver cancer development".Scientific Reports 7.1(2017).
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