UM
Targeting PD-L1 Protein: Translation, Modification and Transport
Wei R.2; Guo L.1; Wang Q.2; Miao J.3; Kwok H.F.1; Lin Y.2
2019
Source PublicationCurrent protein & peptide science
ISSN18755550
Volume20Issue:1Pages:82-91
AbstractProgrammed death ligand 1 (PD-L1) is a cell membrane protein that binds to programmed cell death protein 1 (PD-1) on the effector T cells and transduces immunosuppressive signals. It is now clear that the expression of the PD-L1 protein on the tumor cell surface is critical for tumor cells to escape immunosuppression. At present, more attention is focused on the transcriptional regulation of PDL1 mRNA. However, PD-L1 protein is the functional unit involved in immunotherapy response. It is essential to deeply understand how this membrane protein is regulated post-transcriptionally in tumors and immune cells. In this review, we summarize the recent progress on the translation, modification and transport of PD-L1 protein.
Keywordimmunotherapy modification programmed cell death protein 1 (PD-1) Programmed death ligand 1 (PD-L1) translation transport.
DOI10.2174/1389203719666180928105632
URLView the original
Language英語
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade de Macau
2.Fujian Normal University
3.Nantong University
Recommended Citation
GB/T 7714
Wei R.,Guo L.,Wang Q.,et al. Targeting PD-L1 Protein: Translation, Modification and Transport[J]. Current protein & peptide science,2019,20(1):82-91.
APA Wei R.,Guo L.,Wang Q.,Miao J.,Kwok H.F.,&Lin Y..(2019).Targeting PD-L1 Protein: Translation, Modification and Transport.Current protein & peptide science,20(1),82-91.
MLA Wei R.,et al."Targeting PD-L1 Protein: Translation, Modification and Transport".Current protein & peptide science 20.1(2019):82-91.
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