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Surface state mediated NIR two-photon fluorescence of iron oxides for nonlinear optical microscopy
Liao M.-Y.4; Wu C.-H.1; Lai P.-S.4; Yu J.1; Lin H.-P.2; Liu T.-M.1; Huang C.-C.3
Source PublicationAdvanced Functional Materials
ISSN1616301X 16163028

The development of fluorescent iron oxide nanomaterials is highly desired for multimodal molecular imaging. Instead of incorporating fluorescent dyes on the surface of iron oxides, a ligand-assisted synthesis approach is developed to allow near-infrared (NIR) fluorescence in FeO nanostructures. Using a trimesic acid (TMA)/citrate-mediated synthesis, fabricated FeO nanostructures can generate a NIR two-photon florescence (TPF) peak around 700 nm under the excitation by a 1230-nm femtosecond laser. By tailoring the absorption of FeO nanostructures toward NIR band, the NIR-TPF efficiency can be greatly increased. Through internal etching, surface peeling, and ligand replacement, spectroscopic results validated that such resonantly enhanced NIR-TPF is mediated by surface states with strong NIR-IR absorption. This TPF signal evolution can be generalized to other iron oxide nanomaterials like magnetite nanoparticles and α-FeO nanoplates. Using the developed fluorescent FeO nanostructures, it is demonstrated that their TPF and third harmonic generation (THG) contrast in the nonlinear optical microscopy of live cells. It is anticipated that the synthesized NIR photofunctional FeO will serve as a versatile platform for dual-modality magnetic resonance imaging (MRI) as well as a magnet-guided theranostic agent. Near-infrared (NIR) fluorescence of Fe O and α-FeO nanostructures is generatred by NIR laser excitation. These nanostructures act as cellular probes, as indicated by nonlinear microscopy, and have the potential to be further developed as a bifunctional contrast agents for tracking drug delivery and pharmacokinetics. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KeywordEmission Fe3o4 Magnetite Near Infrared Nonlinear
URLView the original
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000318315100007
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Taiwan University
2.National Cheng Kung University
3.National Yang-Ming University Taiwan
4.National Chung Hsing University
Recommended Citation
GB/T 7714
Liao M.-Y.,Wu C.-H.,Lai P.-S.,et al. Surface state mediated NIR two-photon fluorescence of iron oxides for nonlinear optical microscopy[J]. Advanced Functional Materials,2013,23(16):2044-2051.
APA Liao M.-Y..,Wu C.-H..,Lai P.-S..,Yu J..,Lin H.-P..,...&Huang C.-C..(2013).Surface state mediated NIR two-photon fluorescence of iron oxides for nonlinear optical microscopy.Advanced Functional Materials,23(16),2044-2051.
MLA Liao M.-Y.,et al."Surface state mediated NIR two-photon fluorescence of iron oxides for nonlinear optical microscopy".Advanced Functional Materials 23.16(2013):2044-2051.
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