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Femtosecond laser bone ablation with a high repetition rate fiber laser source
Mortensen L.J.7; Alt C.3; Turcotte R.3; Masek M.3; Liu T.-M.3; Cote D.C.1; Xu C.5; Intini G.7; Lin C.P.3
2015
Source PublicationBiomedical Optics Express
ISSN21567085
Volume6Issue:1Pages:32-42
Abstract

Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Imageguided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process.

Keyword(060.4370) Nonlinear Optics, Fibers (170.1020) Ablation Of Tissue (170.2520) Fluorescence Microscopy (180.4315) Nonlinear Microscopy
DOI10.1364/BOE.6.000032
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000347474800004
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被引频次[WOS]:19   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Affiliation1.Centre de recherche Université Laval Robert-Giffard
2.Harvard Stem Cell Institute
3.Massachusetts General Hospital and Harvard Medical School
4.National Taiwan University
5.Cornell University
6.Boston University
7.Harvard School of Dental Medicine
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Mortensen L.J.,Alt C.,Turcotte R.,et al. Femtosecond laser bone ablation with a high repetition rate fiber laser source[J]. Biomedical Optics Express,2015,6(1):32-42.
APA Mortensen L.J..,Alt C..,Turcotte R..,Masek M..,Liu T.-M..,...&Lin C.P..(2015).Femtosecond laser bone ablation with a high repetition rate fiber laser source.Biomedical Optics Express,6(1),32-42.
MLA Mortensen L.J.,et al."Femtosecond laser bone ablation with a high repetition rate fiber laser source".Biomedical Optics Express 6.1(2015):32-42.
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