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Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms
Huang C.-C.2; Liu T.-M.1
2015-10-26
Source PublicationACS Applied Materials and Interfaces
ISSN19448252 19448244
Volume7Issue:45Pages:25259-25269
Abstract

We have successfully introduced a proton-induced controlled reaction of HAuCl and poly(styrene-alt-maleic acid) (PSMA) sodium salt to prepare triangular and multicore Au@polymer nanoparticles (NPs). The interparticle interactions in the core gave rise to an absorption band at the near-infrared wavelength. The near-infrared optical properties of the resulting Au-polymer nanostructures are highly stable in a physiological environment, which offered strong photo-to-thermal conversion by a moderate continuous-wave 808 nm laser and exhibited multiphoton fluorescence for imaging using a 1230 nm light excitation (femtosecond laser). Exposure of the carboxylate groups at the polymer shell made the surface structure of the Au multicore @polymer NPs directly conjugate Pt(II)-/Pt(IV)-based drugs, which possessed the elimination of the immediate toxicity over the short time and resulted in an anticancer effect after 3 days. A synergistic effect of the chemo-photothermal therapy showed a moderate hyperthermia assistance (<1 W/cm) and better anticancer performance over time compared with the individual treatments. We demonstrated that such PSMA-based methodology not only enables a broad range of chemical material synthesis in the kinetic control to form Au nano-octahedrons and nanotriangles using Br/I ions additives but also could be extended to form Au/FeO@polymer nanocomposites via proton-assisted PSMA self-assembly.

KeywordAnd Chemo-photothermal Therapy Au Nanoparticles Core-shell Multiphoton Imaging Prodrug Delivery Shape Control
DOI10.1021/acsami.5b07110
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000365148600034
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Taiwan University
2.National Cheng Kung University
Recommended Citation
GB/T 7714
Huang C.-C.,Liu T.-M.. Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms[J]. ACS Applied Materials and Interfaces,2015,7(45):25259-25269.
APA Huang C.-C.,&Liu T.-M..(2015).Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms.ACS Applied Materials and Interfaces,7(45),25259-25269.
MLA Huang C.-C.,et al."Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms".ACS Applied Materials and Interfaces 7.45(2015):25259-25269.
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