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Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent: A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging
Chen Y.-W.1; Peng Y.-K.1; Chou S.-W.1; Tseng Y.-J.1; Wu P.-C.1; Wang S.-K.1; Lee Y.-W.1; Shyue J.-J.1; Hsiao J.-K.3; Liu T.-M.1; Chou P.-T.1
2017-06-01
Source PublicationParticle and Particle Systems Characterization
ISSN15214117 09340866
Volume34Issue:6
Abstract

Polydopamine (PDA) preserves universal coating and metal-binding ability, and is suitable for application in synthesizing multifunctional agents. Herein, utilizing mesoporous silica assisted deposition to enhance both heterogeneous nucleation and loading amounts of PDA, the magnetic resonance (MR) T component (PDA-Fe) and MR T/computed tomography (CT)/multiphoton luminescence (MPL) component (FePt) have been successfully integrated in aqueous solution. This four-in-one (T, T, CT, MPL) imaging nanocomposite, FePt@mSiO @PDA-polyethylene glycol (PEG), demonstrated its multi-imaging power both in vitro/in vivo. According to our in vitro/in vivo results, FePt@mSiO@PDA-PEG reveals water-content-dependent property in T MR imaging, which suggests the necessity of having dual-modal MR ability in a single particle for the precision diagnosis. Most importantly, this dual (T,T)-MRI/CT contrast agent is demonstrated complementary to each other in the in vivo testing. PDA coated mesoporous silica also offers an advantage of delayed degradation that prevents adverse effects caused by silica fragments before excretion. The potential of this nanocomposites in both drug carrier and photothermal agent was further evaluated by using doxorubicin and monitoring solution temperature after irradiating 808 nm continuous-wave, respectively The merits of controlled polymerization, enhanced PDA loading, and biofavorable degradation make this methodology promising to other nanoparticle@mSiO for a wide range of bioapplications.

KeywordBiocompatibility Mesoporous Silica Multiscale Imaging Polydopamine
DOI10.1002/ppsc.201600415
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000403919900007
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Taiwan University
2.Academia Sinica, Research Center for Applied Sciences
3.Buddhist Tzu Chi Medical Foundation
4.Tzu Chi University
Recommended Citation
GB/T 7714
Chen Y.-W.,Peng Y.-K.,Chou S.-W.,et al. Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent: A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging[J]. Particle and Particle Systems Characterization,2017,34(6).
APA Chen Y.-W..,Peng Y.-K..,Chou S.-W..,Tseng Y.-J..,Wu P.-C..,...&Chou P.-T..(2017).Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent: A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging.Particle and Particle Systems Characterization,34(6).
MLA Chen Y.-W.,et al."Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent: A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging".Particle and Particle Systems Characterization 34.6(2017).
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