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Androgen receptor co-regulatory networks in castration-resistant prostate cancer
Ying Ying Sung; Edwin Cheung
Source PublicationEndocrine-Related Cancer

Androgen and the androgen receptor (AR) are critical effectors of prostate cancer. Consequently, androgen deprivation therapy is typically employed as a first-line treatment for prostate cancer patients. While initial responses are generally positive, prostate tumors frequently recur and progress to a lethal form known as castration-resistant prostate cancer (CRPC). Recently, considerable effort has been directed toward elucidating the molecular mechanisms of CRPC. Results from both preclinical and clinical studies suggest that AR-mediated signaling persists and remains functionally important in CRPC despite the elimination of androgens. Understanding the role of this pathway in the development of resistance will therefore be critical to identify alternative diagnostic markers as well as more effective therapies for the treatment of CRPC. Using next-generation sequencing and other high-throughput approaches, numerous groups are beginning to identify the key differences in the transcriptional regulatory and gene expression programs between androgen-dependent and CRPC. A number of mechanisms have been proposed for the differences and these mostly involve alterations to components of the AR co-regulatory network. In this review, we summarize current knowledge on co-regulators of the AR and discuss their potential roles in CRPC. It is anticipated that a deeper understanding of these factors will undercover new targets that can assist in the diagnosis and treatment of CRPC

KeywordAndrogen Receptor Co-regulators Prostate Cancer Castration Resistant
Indexed BySCI
WOS Research AreaOncology ; Endocrinology & Metabolism
WOS SubjectOncology ; Endocrinology & Metabolism
WOS IDWOS:000334279600003
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorEdwin Cheung
AffiliationCancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore
Recommended Citation
GB/T 7714
Ying Ying Sung,Edwin Cheung. Androgen receptor co-regulatory networks in castration-resistant prostate cancer[J]. Endocrine-Related Cancer,2014,21(1):R1-R11.
APA Ying Ying Sung,&Edwin Cheung.(2014).Androgen receptor co-regulatory networks in castration-resistant prostate cancer.Endocrine-Related Cancer,21(1),R1-R11.
MLA Ying Ying Sung,et al."Androgen receptor co-regulatory networks in castration-resistant prostate cancer".Endocrine-Related Cancer 21.1(2014):R1-R11.
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