UM  > 健康科學學院
Androgen receptor co-regulatory networks in castration-resistant prostate cancer
Ying Ying Sung; Edwin Cheung
2014
Source PublicationEndocrine-Related Cancer
ISSN1351-0088
Volume21Issue:1Pages:R1-R11
Abstract

Androgen and the androgen receptor (AR) are critical effectors of prostate cancer. Consequently, androgen deprivation therapy is typically employed as a first-line treatment for prostate cancer patients. While initial responses are generally positive, prostate tumors frequently recur and progress to a lethal form known as castration-resistant prostate cancer (CRPC). Recently, considerable effort has been directed toward elucidating the molecular mechanisms of CRPC. Results from both preclinical and clinical studies suggest that AR-mediated signaling persists and remains functionally important in CRPC despite the elimination of androgens. Understanding the role of this pathway in the development of resistance will therefore be critical to identify alternative diagnostic markers as well as more effective therapies for the treatment of CRPC. Using next-generation sequencing and other high-throughput approaches, numerous groups are beginning to identify the key differences in the transcriptional regulatory and gene expression programs between androgen-dependent and CRPC. A number of mechanisms have been proposed for the differences and these mostly involve alterations to components of the AR co-regulatory network. In this review, we summarize current knowledge on co-regulators of the AR and discuss their potential roles in CRPC. It is anticipated that a deeper understanding of these factors will undercover new targets that can assist in the diagnosis and treatment of CRPC

KeywordAndrogen Receptor Co-regulators Prostate Cancer Castration Resistant
DOIhttps://doi.org/10.1530/ERC-13-0326
Indexed BySCI
Language英语
WOS Research AreaOncology ; Endocrinology & Metabolism
WOS SubjectOncology ; Endocrinology & Metabolism
WOS IDWOS:000334279600003
全文获取链接
引用统计
被引频次[WOS]:12   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorEdwin Cheung
AffiliationCancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore
推荐引用方式
GB/T 7714
Ying Ying Sung,Edwin Cheung. Androgen receptor co-regulatory networks in castration-resistant prostate cancer[J]. Endocrine-Related Cancer,2014,21(1):R1-R11.
APA Ying Ying Sung,&Edwin Cheung.(2014).Androgen receptor co-regulatory networks in castration-resistant prostate cancer.Endocrine-Related Cancer,21(1),R1-R11.
MLA Ying Ying Sung,et al."Androgen receptor co-regulatory networks in castration-resistant prostate cancer".Endocrine-Related Cancer 21.1(2014):R1-R11.
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
Google Scholar
中相似的文章 Google Scholar
[Ying Ying Sung]的文章
[Edwin Cheung]的文章
Baidu academic
中相似的文章 Baidu academic
[Ying Ying Sung]的文章
[Edwin Cheung]的文章
Bing Scholar
中相似的文章 Bing Scholar
[Ying Ying Sung]的文章
[Edwin Cheung]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。