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Sequencing the transcriptional network of androgen receptor in prostate cancer
Kern Rei Chng1,4; Edwin Cheung1,2,3
2013-11-01
Source PublicationCancer Letters
ISSN0304-3835
Volume340Issue:2Pages:254-260
Abstract

The progression of prostate cancer is largely dependent on the activity of the androgen receptor (AR), which in turn, correlates with the net output of the AR transcriptional regulatory network. A detailed and thorough understanding of the AR transcriptional regulatory network is therefore critical in the strategic manipulation of AR activity for the targeted eradication of prostate cancer cells. In this mini-review, we highlight some of the novel and unexpected mechanistic and functional insights of the AR transcriptional network derived from recent targeted sequencing (ChIP–Seq) studies of AR and its coregulatory factors in prostate cancer cells.

KeywordChromatin Immunoprecipitation High-throughput Sequencing Androgen Receptor Prostate Cancer Transcriptional Network
DOIhttp://doi.org/10.1016/j.canlet.2012.11.009
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000327293400015
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorEdwin Cheung
Affiliation1.Cancer Biology and Pharmacology, Genome Institute of Singapore, A STAR (Agency for Science, Technology and Research), Singapore 138672, Singapore
2.Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
3.School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
4.Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117573, Singapore
Recommended Citation
GB/T 7714
Kern Rei Chng,Edwin Cheung. Sequencing the transcriptional network of androgen receptor in prostate cancer[J]. Cancer Letters,2013,340(2):254-260.
APA Kern Rei Chng,&Edwin Cheung.(2013).Sequencing the transcriptional network of androgen receptor in prostate cancer.Cancer Letters,340(2),254-260.
MLA Kern Rei Chng,et al."Sequencing the transcriptional network of androgen receptor in prostate cancer".Cancer Letters 340.2(2013):254-260.
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