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Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer
Mei Hui Liu1,2; Edwin Cheung2
2014-01-25
Source PublicationMolecular and Cellular Endocrinology
ISSN0303-7207
Volume382Issue:1Pages:624-632
Abstract

Estrogen induces the binding of ERa to thousands of locations in the breast cancer genome, preferring intergenic and distal regions rather than near the promoters of estrogen-regulated genes. With recent technological innovations in mapping and characterization of global chromatin organization, evidence now indicates ERa mediates long-range chromatin interactions to control gene transcription. The principles that govern how ERa communicates with their putative target genes via chromosomal interactions are also beginning to unravel. Herein, we summarize our current knowledge on the functional signifi- cance of chromatin looping in estrogen-mediated transcription. ERa collaborative factors and other players that contribute to define the genomic interactions in breast cancer cells will also be discussed. Defects in chromatin organization are emerging key players in diseases such as cancer, thus understanding how ERa-mediated chromatin looping affects genome organization will clarify the receptor’s role in estrogen responsive pathways sensitive to defects in chromatin organization.

KeywordLong-range Chromatin Interaction Chia-pet 3c Distal Regulation Estrogen Receptor-a
DOIhttp://dx.doi.org/10.1016/j.mce.2013.09.019
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Endocrinology & Metabolism
WOS SubjectCell Biology ; Endocrinology & Metabolism
WOS IDWOS:000330421600068
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorEdwin Cheung
Affiliation1.Food Science and Technology Programme, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
2.Cancer Biology and Pharmacology, Genome Institute of Singapore, A⁄STAR (Agency for Science, Technology and Research), Singapore 138672, Singapore
Recommended Citation
GB/T 7714
Mei Hui Liu,Edwin Cheung. Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer[J]. Molecular and Cellular Endocrinology,2014,382(1):624-632.
APA Mei Hui Liu,&Edwin Cheung.(2014).Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer.Molecular and Cellular Endocrinology,382(1),624-632.
MLA Mei Hui Liu,et al."Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer".Molecular and Cellular Endocrinology 382.1(2014):624-632.
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