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A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration
Hung, Clara Hiu-Ling1,3; Cheng, Sally Shuk-Yee1; Cheung, Yuen-Ting1; Wuwongse, Suthicha1; Zhang, Natalie Qishan1; Ho, Yuen-Shan4; Lee, Simon Ming-Yuen3; Chang, Raymond Chuen-Chung1,2
2018-04
Source PublicationREDOX BIOLOGY
ISSN2213-2317
Volume14Pages:7-19
Abstract

Mitochondrial fragmentation due to fission/fusion imbalance has often been linked to mitochondrial dysfunction and apoptosis in neurodegeneration. Conventionally, it is believed that once mitochondrial morphology shifts away from its physiological tubular form, mitochondria become defective and downstream apoptotic signaling pathways are triggered. However, our study shows that beta-amyloid (A beta) induces morphological changes in mitochondria where they become granular-shaped and are distinct from fragmented mitochondria in terms of both morphology and functions. Accumulation of mitochondrial reactive oxygen species triggers granular mitochondria formation, while mitoTEMPO (a mitochondria-targeted superoxide scavenger) restores tubular mitochondrial morphology within A beta-treated neurons. Interestingly, modulations of mitochondria fission and fusion by genetic and pharmacological tools attenuated not only the induction of granular mitochondria, but also mitochondrial superoxide levels in A beta - treated neurons. Our study shows a reciprocal relationship between mitochondrial dynamics and reactive oxygen species and provides a new potential therapeutic target at early stages of neurodegenerative disease pathogenesis.

KeywordAlzheimer's Disease Beta-amyloid Mitochondria Fission And Fusion Drp-1 Neurodegeneration
DOI10.1016/j.redox.2017.08.010
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000419811100002
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China
3.Institute of Chinese Medical Sciences, University of Macau, Macau, China
4.School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Hung, Clara Hiu-Ling,Cheng, Sally Shuk-Yee,Cheung, Yuen-Ting,et al. A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration[J]. REDOX BIOLOGY,2018,14:7-19.
APA Hung, Clara Hiu-Ling.,Cheng, Sally Shuk-Yee.,Cheung, Yuen-Ting.,Wuwongse, Suthicha.,Zhang, Natalie Qishan.,...&Chang, Raymond Chuen-Chung.(2018).A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration.REDOX BIOLOGY,14,7-19.
MLA Hung, Clara Hiu-Ling,et al."A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration".REDOX BIOLOGY 14(2018):7-19.
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