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Interpolated average CT for attenuation correction in PET - A simulation study
Greta S. P. Mok1; Tao Sun1; Tung-Hsin Wu2; Mu-Bai Chang3; Tzung-Chi Huang2
2012-03-26
Conference NameIEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors
Source PublicationIEEE Nuclear Science Symposium Conference Record
Pages4121-4125
Conference DateOCT 23-29, 2011
Conference PlaceValencia, SPAIN
Abstract

Previously we proposed using an interpolated average CT (IACT) method for attenuation correction (AC) in PET, which is a good low-dose approximation of cine average CT (CACT) to reduce misalignments and improve quantification in PET/CT. This study aims to evaluate the performance of IACT for different motion amplitudes. We used the digital 4D Extended Cardiac Torso phantom (XCAT) to simulate maximum of 2 cm, 3 cm and 4 cm respiratory motions. The respiratory cycle was divided into 13 phases, with average activity and attenuation maps to represent F-FDG distribution with average respiratory motions and CACT respectively. The end-inspiration, end-expiration and the mid-respiratory phases represented 3 different helical CTs (HCT-1, HCT-5 and HCT-8). The IACTs were generated using: (a) 2 extreme + 11 interpolated phases (IACT ); (b) 2 phases right after the extreme phases + 11 interpolated phases (IACT ); (c) 4 original + 9 interpolated phases (IACT ). A spherical lesion with target-to-background ratio (TBR) of 4:1 and diameter of 25 mm was placed in the base of right lung. The noise-free and noisy sinograms with attenuation modeling were generated and reconstructed with different noise-free and noisy AC maps (CACT, HCTs and IACTs) by STIR (Software for Tomographic Image Reconstruction) respectively, using OS-EM with up to 300 updates. Normalized-mean square error (NMSE), mutual information (MI), TBR and image profiles were analyzed. The PET reconstructed images with AC using CACT showed least difference as compared to the original phantom, followed by IACT4 , IACT , IACT , HCT-5 and HCT-1/HCT-8. Significant artifacts were observed in the reconstructed images using HCTs for AC. The MI differences between IACT and IACT /CACT were <0.41% and <2.17% respectively. With a slight misplacement of the two extreme phases, IACT was still comparable to IACT with difference of <2.23%. The IACT is a robust, accurate low dose alternate to CACT and works well for over 90% of the clinical patients. © 2011 IEEE.

DOIhttp://doi.org/10.1109/NSSMIC.2011.6153785
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Physics ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectEngineering, Electrical & Electronic ; Physics, Applied ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000304755604072
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Document TypeConference paper
CollectionDEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Affiliation1.Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, China
2.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taiwan, China
3.Graduate Institute of Clinical Medical Science, China Medical University, Taiwan, China
First Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Greta S. P. Mok,Tao Sun,Tung-Hsin Wu,et al. Interpolated average CT for attenuation correction in PET - A simulation study[C],2012:4121-4125.
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