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The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT
Tung-Hsin Wu1; Kun-Mu Lu2; Nien-Yun Wu1,3; Shyh-Jen Wang3; Greta S.P. Mok5; Bang-Hung Yang1,3; Ching-Ching Yang4
2015-03-06
Source PublicationNuclear Medicine Communications
ISSN14735628 01433636
Volume36Issue:4Pages:376-385
Abstract

Introduction The purpose of this study was to investigate the feasibility of using low-dose computed tomography (CT) in coronary artery calcium scoring and PET attenuation correction for patients in different weight categories undergoing cardiac PET/CT examinations. Materials and methods Calcium scoring computed tomography (CSCT) scans and PET scans of anthropomorphic cardiac phantoms simulating normalweight, mildly obese, and severely obese patients were acquired with a hybrid PET/CT scanner. CSCT images were acquired at 120 kVp, with tube current ranging from 10 to 550 mA. PET scans were performed in three-dimensional mode, with acquisition time of 3 min/bed position. The image quality of cardiac PET/CT was evaluated by assessing the signal-to-noise ratio. CT-based coronary artery calcium quantification was performed using the Agatston scoring system. Results On the basis of our results, the CSCT protocols using tube currents of 50 and 150mA should be able to achieve the lowest possible radiation dose while maintaining the desired image quality for normal-weight and mildly obese patients undergoing cardiac PET/CT examinations, respectively. When the proposed low-dose CSCT protocols were performed, radiation dose could be reduced by 83.34 and 50% compared with those from CSCT scans acquired with standard tube current settings for normal-weight and mildly obese patients, respectively. In the scanning of severely obese patients, an increase in tube voltage or current would help improve the reliability of image information provided by cardiac PET/CT. Conclusion Our study demonstrated the feasibility of lowdose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT to examine patients in different weight categories. The calculations performed in this work should be able to provide practical information to achieve necessary diagnostic information while keeping radiation dose as low as reasonably achievable.

KeywordAgatston Score Attenuation Correction Cardiac Pet/ct Radiation Dose
DOIhttp://doi.org/10.1097/MNM.0000000000000251
URLView the original
Indexed BySCI
Language英语
WOS Research AreaRadiology ; Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000352732000010
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorChing-Ching Yang
Affiliation1.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University
2.Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital
3.Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei
4.Department of Medical Imaging and Radiological Sciences, Tzu-Chi College of Technology, Hualien, Taiwan, ROC
5.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Tung-Hsin Wu,Kun-Mu Lu,Nien-Yun Wu,et al. The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT[J]. Nuclear Medicine Communications,2015,36(4):376-385.
APA Tung-Hsin Wu.,Kun-Mu Lu.,Nien-Yun Wu.,Shyh-Jen Wang.,Greta S.P. Mok.,...&Ching-Ching Yang.(2015).The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT.Nuclear Medicine Communications,36(4),376-385.
MLA Tung-Hsin Wu,et al."The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT".Nuclear Medicine Communications 36.4(2015):376-385.
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