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The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population
Yun C.-H.1,2; Longenecker C.T.3; Chang H.-R.4,5; Mok G.S.P.6; Sun J.-Y.1; Liu C.-C.7,8,9; Kuo J.-Y.10,11; Hung C.-L.1,10,11; Wu T.-H.1; Yeh H.-I.10,11; Yang F.-S.2; Lee J.J.S.1; Hou C.J.Y.10,11; Cury R.C.12; Bezerra H.G.3
2016
Source PublicationJournal of Cardiovascular Computed Tomography
ISSN1876861X 19345925
Volume10Issue:1Pages:44-51
Abstract

Aim: To describe the relationship between a novel measurement of peri-arotic root fat and ultrasound measures of carotid artery remodeling. Materials and methods: We studied 1492 consecutive subjects (mean age: 51.04 ± 8.97 years, 27% females) who underwent an annual cardiovascular risk survey in Taiwan. Peri-aortic root fat (PARF) was assessed by cardiac CT using three-dimensional (3D) volume assessment. Carotid artery morphology and remodeling were assessed by ultrasound. We explored the relationships between PARF volumes, cardiometabolic risk profiles and carotid morphology and remodeling. Results: Mean PARF volume in current study was 20.8 ± 10.6 ml. PARF was positively correlated with measures of general adiposity, systemic inflammation, and several traditional cardiometabolic risk profiles (all p < 0.001) and successfully predicted metabolic syndrome (MetS) (AUROC: 0.75, 95%, confidence interval: 0.72-0.77). Higher PARF was independently associated with increased carotid artery intima-media thickness (IMT) (β-coef.: 0.08) and diameter (β-coef.: 0.08, both p < 0.05) after accounting for age, sex, BMI and other cardiovascular risk factors. The addition of PARF beyond metabolic syndrome components significantly provided incremental prediction value for abnormal IMT (δAUROC: 0.053, p = 0.0021). Conclusion: Peri-aortic root fat is associated with carotid IMT, even after adjustment for cardiometabolic risks, age and coronary atherosclerosis. Further research studies are warranted to identify the mediators of downstream pathophysiologic effects on carotid arteries by PARF and understand the mechanisms related to this correlation.

KeywordAdipose Tissue Cardiovascular Disease Risk Factors Carotid Artery Computed Tomography Metabolic Syndrome
DOIhttp://doi.org/10.1016/j.jcct.2015.10.002
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCardiovascular System & Cardiology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectCardiac & Cardiovascular Systems ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000369115100006
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHung C.-L.; Wu T.-H.
Affiliation1.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
2.Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan
3.Division of Cardiology, Department of Internal Medicine, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University, Cleveland, OH, USA
4.Institute of Health Policy and Management of Public Health, National Taiwan University, Taipei, Taiwan
5.Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
6.Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Macau
7.Graduate Institute of Health Care Organization Administration, College of Public Health National Taiwan University, Taipei, Taiwan
8.Health Evaluation Center, Mackay Memorial Hospital, Taipei, Taiwan
9.Department of Medical Technology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan
10.Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
11.Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, New Taipei, Taiwan
12.Cardiovascular MRI and CT Program, Baptist Cardiac Vascular Institute, Miami, USA
Recommended Citation
GB/T 7714
Yun C.-H.,Longenecker C.T.,Chang H.-R.,et al. The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population[J]. Journal of Cardiovascular Computed Tomography,2016,10(1):44-51.
APA Yun C.-H..,Longenecker C.T..,Chang H.-R..,Mok G.S.P..,Sun J.-Y..,...&Bezerra H.G..(2016).The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population.Journal of Cardiovascular Computed Tomography,10(1),44-51.
MLA Yun C.-H.,et al."The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population".Journal of Cardiovascular Computed Tomography 10.1(2016):44-51.
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