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Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine
Mok G.S.P.1; Zhang D.1; Chen S.-Z.2; Yuan J.3; Griffith J.F.2; Wang Y.X.J.2
2016-07-01
Source PublicationJournal of Orthopaedic Translation
ISSN2214031X
Volume6Pages:34-41
Abstract

Objective: To compare three methods commonly used in the literature to define intervertebral disc nucleus pulposus (NP) and annulus fibrosus (AF) on magnetic resonance (MR) images. Materials and methods: Fifty-two patients (26 males and 26 females; age range, 23-76 years) were recruited for this study; they underwent standard T1/T2-weighted MR imaging, and T2 and T1rho mapping acquisitions. The corresponding midsagittal images were analysed and a total of 256 discs were evaluated, using three different region-of-interest (ROI) drawing methods: (1) radiologist-guided manual ROI (M-ROI); (2) five square ROIs where each measured 20% of the midline disc diameter (5-ROI); and (3) seven square ROIs placed horizontally from anterior to posterior (7-ROI) to define NP and AF. The agreement between the three ROI methods was assessed using intraclass correlation coefficient values and Bland-Altman plots. Results: Inner AF and NP could not be differentiated on T1/T2-weighted MR imaging, T2 maps, or T1rho maps. The intraclass correlation coefficient values were all > 0.75 when comparing the 5-/7-ROI methods with the M-ROI methods for NP, and 0.167-0.488 for AF when comparing the 7-ROI method with the M-ROI method. The intraclass correlation coefficient values for AF increased to 0.378-0.582 for the M-ROI method compared with the 5-ROI method. Comparable results were obtained with Bland-Altman plots. Conclusion: The 5-/7-ROI methods agreed with the M-ROI approach for NP selection, while the agreement with AF was moderate to poor, with the 5-ROI method showing slight advantage over the 7-ROI method. Cautions should be taken to interpret the MR relaxometry findings when 5-/7-ROI methods are used to select AF.

KeywordAnnulus Fibrosus Degeneration Disc Magnetic Resonance Imaging Nucleus Pulposus Region Of Interest
DOIhttp://doi.org/10.1016/j.jot.2016.02.003
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOrthopedics
WOS SubjectOrthopedics
WOS IDWOS:000379258300005
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang Y.X.J.
Affiliation1.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, University of Macau, Macau Special Administrative Region
2.Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region
3.Universidade de MacauMedical Physics and Research Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong Special Administrative Region
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Mok G.S.P.,Zhang D.,Chen S.-Z.,et al. Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine[J]. Journal of Orthopaedic Translation,2016,6:34-41.
APA Mok G.S.P.,Zhang D.,Chen S.-Z.,Yuan J.,Griffith J.F.,&Wang Y.X.J..(2016).Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine.Journal of Orthopaedic Translation,6,34-41.
MLA Mok G.S.P.,et al."Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine".Journal of Orthopaedic Translation 6(2016):34-41.
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