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Evaluation of Stationary and Semi-stationary Acquisitions from Dual-head Multi-pinhole Collimator for Myocardial Perfusion SPECT
Yan P.1; Chen L.1; Tsui B.M.W.2; Mok G.S.P.1
2016-10-01
Source PublicationJournal of Medical and Biological Engineering
ISSN21994757 16090985
Volume36Issue:5Pages:675-685
Abstract

This study investigates the performance of different stationary and semi-stationary multi-pinhole collimator (MPH) designs with a dual-head L-mode configuration as compared to that of a conventional low-energy high-resolution (LEHR) collimator for myocardial perfusion (MP) single-photon emission computed tomography (SPECT). The target field-of-view for the heart was 16 cm with a target resolution of 1 cm. The design parameters were determined by maximizing the detection efficiency based on the system design constraints. Three stationary designs (L-modes I to III) and semi-stationary designs (S-modes I to III) with four detector positions (i.e., 2 L-mode positions at various angles apart) were evaluated. We used the XCAT phantom with Tc-sestamibi distribution and a three-dimensional analytical MPH/LEHR projector to generate noise-free and noisy projections, which were reconstructed using the maximum-likelihood expectation–maximization algorithm with up to 180 updates. A two-dimensional (2D) region-of-interest with 32 × 32 pixels covering the central axial slice of the left ventricle was analyzed using normalized mean-squared error (NMSE), normalized standard deviation (NSD), and a 2D bias map. The optimized MPH collimator design parameters are 12 pinholes, an acceptance angle of 51°, an aperture size of 4.6 mm, a collimator length of 15.8 cm, and an imaging distance of 18.6 cm. The NMSE of L-mode II (0.326) was the lowest among all stationary designs. S-mode II/40° provided the lowest NMSE result (0.14) among all acquisitions, and was 36.1 % better than LEHR. The NSD-NMSE result showed that S-mode II/40° had the best NMSE-NSD trade-off. The 2D bias map of S-mode II/40° approached that of LEHR. Semi-stationary MPH acquisition substantially improved image quality as compared to those obtained with a full stationary design and a conventional LEHR for MP SPECT.

KeywordMulti-pinhole Myocardial Perfusion Single-photon Emission Computed Tomography (Spect) Stationary Acquisition
DOIhttp://doi.org/10.1007/s40846-016-0169-1
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
WOS IDWOS:000387227600008
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorMok G.S.P.
Affiliation1.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology,University of Macau,Taipa,China
2.The Russell H. Morgan Department of Radiology and Radiological Science, Division of Medical Imaging Physics,Johns Hopkins University,Baltimore,USA
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Yan P.,Chen L.,Tsui B.M.W.,et al. Evaluation of Stationary and Semi-stationary Acquisitions from Dual-head Multi-pinhole Collimator for Myocardial Perfusion SPECT[J]. Journal of Medical and Biological Engineering,2016,36(5):675-685.
APA Yan P.,Chen L.,Tsui B.M.W.,&Mok G.S.P..(2016).Evaluation of Stationary and Semi-stationary Acquisitions from Dual-head Multi-pinhole Collimator for Myocardial Perfusion SPECT.Journal of Medical and Biological Engineering,36(5),675-685.
MLA Yan P.,et al."Evaluation of Stationary and Semi-stationary Acquisitions from Dual-head Multi-pinhole Collimator for Myocardial Perfusion SPECT".Journal of Medical and Biological Engineering 36.5(2016):675-685.
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