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Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds
Yao, Shun1,2; Zhang, Gaojian3; Wang, Haiyan1,2; Song, Jinjin4; Liu, Tianyan4; Yang, Mingdi1,2,6; Yu, Jianhua1,2; Yang, Xingyuan3; Tian, Yupeng1,2; Zhang, Xuanjun5; Zhou, Hongping1,2
2018-11
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume272Pages:574-581
Abstract

Two novel similar structural coumarin-based fluorescent compounds L1 and L2 employing ether oxygen chain and 2 - pyridine unit had been prepared to explore the effect of structural adjustment on property. The prepared L2 through slightly adjusting structure of L1 exhibited the prominent fluorescence responses to Hg2+ and Cu2+ in H2O, which could monitor the corresponding metals ion in mitochondria of Hela cells, but L1 only recognized Hg2+ through turn-on fluorescence response in CH3OH/H2O, fluorescence co-localization studies illustrated that the L1 mainly located at lysosome. The recognition mechanism had been established by H-1 NMR titration, Job's plot, MAlDI-TOF mass spectrometry and single crystal structure. Bio-imaging experiments revealed that L1 and L2 could qualitatively monitor Hg2+ or Cu2+ in Hela cells and mouse kidney tissues.

KeywordFluorescence Probes Mercuric Ion Copper Ion Lysosome Mitochondria Bio-imaging Application
DOI10.1016/j.snb.2018.05.143
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000439715000066
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
2.AnHui Prov Key Lab Chem Inorgan Organ Hybrid Func, Key Lab Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Anhui, Peoples R China
3.Anhui Univ, Inst Phys Sci & Informat Technol, Fac Hlth Sci, Hefei 230601, Anhui, Peoples R China
4.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China
5.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
6.Anhui Jianzhu Univ, Sch Mat & Chem Engn, Hefei 230601, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Yao, Shun,Zhang, Gaojian,Wang, Haiyan,et al. Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,272:574-581.
APA Yao, Shun.,Zhang, Gaojian.,Wang, Haiyan.,Song, Jinjin.,Liu, Tianyan.,...&Zhou, Hongping.(2018).Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds.SENSORS AND ACTUATORS B-CHEMICAL,272,574-581.
MLA Yao, Shun,et al."Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds".SENSORS AND ACTUATORS B-CHEMICAL 272(2018):574-581.
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