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Preparation of nanomagnetic absorbent for partition coefficient measurement
Tsang S.C.2; Yu C.H.2; Gao X.2; Tam K.Y.1
2006-12-11
Source PublicationInternational Journal of Pharmaceutics
ISSN03785173
Volume327Issue:1-2Pages:139-144
AbstractIn this paper, we report a new method based on supercritical carbon dioxide (scCO) to fill and distribute the porous magnetic nanoparticles with n-octanol in a homogeneous manner. The high solubility of n-octanol in scCO and high diffusivity and permeability of the fluid allow efficient delivery of n-octanol into the porous magnetic nanoparticles. Thus, the n-octanol-loaded magnetic nanoparticles can be readily dispersed into aqueous buffer (pH 7.40) to form a homogenous suspension consisting of nano-sized n-octanol droplets. We refer this suspension as the n-octanol stock solution. The n-octanol stock solution is then mixed with bulk aqueous phase (pH 7.40) containing an organic compound prior to magnetic separation. The small-size of the particles and the efficient mixing enable a rapid establishment of the partition equilibrium of the organic compound between the solid supported n-octanol nano-droplets and the bulk aqueous phase. UV-vis spectrophotometry is then applied to determine the concentration of the organic compound in the aqueous phase both before and after partitioning (after magnetic separation). As a result, log D values of organic compounds of pharmaceutical interest determined by this modified method are found to be in excellent agreement with the literature data. © 2006 Elsevier B.V. All rights reserved.
KeywordMagnetic nanoparticle Magnetic separation Partition coefficient Porous Supercritical fluid
DOI10.1016/j.ijpharm.2006.07.031
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.AstraZeneca
2.University of Reading
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GB/T 7714
Tsang S.C.,Yu C.H.,Gao X.,et al. Preparation of nanomagnetic absorbent for partition coefficient measurement[J]. International Journal of Pharmaceutics,2006,327(1-2):139-144.
APA Tsang S.C.,Yu C.H.,Gao X.,&Tam K.Y..(2006).Preparation of nanomagnetic absorbent for partition coefficient measurement.International Journal of Pharmaceutics,327(1-2),139-144.
MLA Tsang S.C.,et al."Preparation of nanomagnetic absorbent for partition coefficient measurement".International Journal of Pharmaceutics 327.1-2(2006):139-144.
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