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Chemoembolization agents for cancer treatment
Tam K.Y.1; Leung K.C.-F.2; Wang Y.-X.J.3
2011-09-18
Source PublicationEuropean Journal of Pharmaceutical Sciences
ISSN09280987 18790720
Volume44Issue:1-2Pages:1-10
Abstract

Chemoembolization has been used in the field of interventional oncology. Although practiced widely, it has only recently been demonstrated that the use of transarterial chemoembolization (TACE) provides a survival benefit based on randomized controlled trials. TACE combines the effect of targeted chemotherapy with the effect of ischemic necrosis induced by arterial embolization. Most of the TACE procedures have been based on iodized oil utilizing its microembolic and drug-carrying characteristics. Recently, there have been efforts to improve the delivery of chemotherapeutic agents to a tumor, which leads to the development of drug-eluting particles. In this review, we will describe the properties and efficacy of some chemoembolization agents which are commercially available and/or currently under clinical investigations. The potential and future of this new form of transcatheter arterial therapy for liver cancer will be discussed. © 2011 Elsevier B.V. All rights reserved.

KeywordChemoembolization Drug-eluting Particles Hepatocellular Carcinoma Lipiodol Microspheres
DOIhttp://doi.org/10.1016/j.ejps.2011.06.013
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000295109400001
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Cited Times [WOS]:44   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang Y.-X.J.
Affiliation1.AstraZeneca
2.Chinese University of Hong Kong
3.Prince of Wales Hospital Hong Kong
Recommended Citation
GB/T 7714
Tam K.Y.,Leung K.C.-F.,Wang Y.-X.J.. Chemoembolization agents for cancer treatment[J]. European Journal of Pharmaceutical Sciences,2011,44(1-2):1-10.
APA Tam K.Y.,Leung K.C.-F.,&Wang Y.-X.J..(2011).Chemoembolization agents for cancer treatment.European Journal of Pharmaceutical Sciences,44(1-2),1-10.
MLA Tam K.Y.,et al."Chemoembolization agents for cancer treatment".European Journal of Pharmaceutical Sciences 44.1-2(2011):1-10.
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