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Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules
Velicky M.1; Tam K.Y.2; Dryfe R.A.W.1
2012-09-01
Source PublicationJournal of Electroanalytical Chemistry
ISSN15726657
Volume683Pages:94-102
Abstract

Liquid/liquid electrochemistry has been used to study the transfer of weakly ionised species across the interface between water and 1,2-dichloroethane. It is shown that while transfer of a fully ionised species can be readily used for determination of its diffusion coefficient, transfer of a partially ionised species, such as many common pharmaceutical agents, involves complex ionisation/distribution behaviour, which invalidates the conventional analysis. As a result, the aqueous diffusion coefficient of the transferred species is underestimated by at least one order of magnitude. An alternative method to study the transfer of partially ionised drug molecules employing a rotating liquid/liquid interface is proposed and reported. The alternative approach, which is based on a previously reported rotating diffusion cell approach, employs a lipophilic membrane that stabilises the liquid/liquid interface and allows stirring. This hydrodynamically controlled configuration was successfully applied to transfer of partially ionised drug species, and expected values of the aqueous diffusion coefficient were obtained. © 2012 Elsevier B.V. All rights reserved.

KeywordDiffusion Hydrodynamic Voltammetry Ion Transfer Liquid/liquid Electrochemistry Membrane Rotating Interface
DOI10.1016/j.jelechem.2012.07.037
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry
WOS SubjectChemistry, Analytical ; Electrochemistry
WOS IDWOS:000310126300015
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Citation statistics
Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.University of Manchester
2.AstraZeneca
Recommended Citation
GB/T 7714
Velicky M.,Tam K.Y.,Dryfe R.A.W.. Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules[J]. Journal of Electroanalytical Chemistry,2012,683:94-102.
APA Velicky M.,Tam K.Y.,&Dryfe R.A.W..(2012).Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules.Journal of Electroanalytical Chemistry,683,94-102.
MLA Velicky M.,et al."Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules".Journal of Electroanalytical Chemistry 683(2012):94-102.
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