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Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift
Francine E.2; Tsakmaka C.2; Mohr S.2; Fielden P.R.2; Goddard N.J.2; Booth J.1; Tam K.Y.1
2013-11-26
Source PublicationAnalyst
ISSN13645528 00032654
Volume138Issue:1Pages:339-345
AbstractThe purpose of this study is to develop a droplet-based microfluidic device capable of monitoring drug precipitation upon a shift from gastric pH (pH 1.5) to intestinal pH (pH 6.5–7.0). The extent of precipitation occurring in droplets over time was measured using a novel on-chip laser scattering technique specifically developed for this study. The precipitation of ketoconazole, a poorly water-soluble basic drug, was investigated under different concentrations and pH values. It has been shown that the drug precipitates rapidly under supersaturation. Two water-soluble aqueous polymers, namely, polyvinylpyrrolidone (PVP) and hydroxypropylmethylcellulose (HPMC) have been evaluated as precipitation inhibitors. HPMC was shown to be the most potent precipitation inhibitor. It is envisaged that the microfluidic pH-shift method developed in this study would form a proof-of-concept study, towards the development of a high throughput method for screening pharmaceutical excipients/precipitation inhibitors. © 2012 The Royal Society of Chemistry.
DOI10.1039/c2an36364j
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.AstraZeneca
2.University of Manchester
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GB/T 7714
Francine E.,Tsakmaka C.,Mohr S.,et al. Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift[J]. Analyst,2013,138(1):339-345.
APA Francine E..,Tsakmaka C..,Mohr S..,Fielden P.R..,Goddard N.J..,...&Tam K.Y..(2013).Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift.Analyst,138(1),339-345.
MLA Francine E.,et al."Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift".Analyst 138.1(2013):339-345.
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