UM
Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease
Tian Y.1; Ding Z.1; Tam K.Y.2; Wang Z.1; Zhang H.1; Zhao D.1; Zhao Y.1; Xu W.1; Zheng S.1
2015-09-01
Source PublicationADMET and DMPK
ISSN18487718
Volume3Issue:3Pages:274-280
AbstractResting-state functional magnetic resonance imaging was utilized to measure the amplitude low frequency fluctuations (ALFF) in human subjects with Alzheimer's disease (AD) and normal control (NC). Two specific frequency bands (Slow5: 0.01-0.027 Hz and Slow4: 0.027-0.073 Hz) were analysed in the main cognitive control related four subregions of the right ventral lateral prefrontal cortex (VLPFC), i.e. IFJ, posterior-VLPFC, mid-VLPFC, and anterior-VLPFC. Differences in ALFF values between the AD and the NC group were found throughout the subregions of the right VLPFC. Compared to normal control group, decreased ALFF values were observed in AD patients in the IFJ (in two given frequency bands), and the mid-VLPFC (in Slow5). In contrast, increased ALFF valued were observed in AD patients in the posterior- and anterior-VLPFC (in both Slow5 and Slow4), and also in the mid-VLPFC in Slow4. Moreover, significant ALFF differences between the IFJ and three other subregions of the right VLPFC were found. Furthermore, ALFF values in the right VLPFC showed significant correlations with the time course of disease. Taken together, our findings suggest that AD patients have largely abnormalities in intrinsic neural oscillations which are in line with the AD pathophysiology, and further reveal that the abnormalities are dependent on specific frequency bands. Thus, frequency-domain analyses of the ALFF may provide a useful tool to investigate the AD pathophysiology.
KeywordAD ALFF Rs-fMRI Top-down modulation VLPFC
DOI10.5599/admet.3.3.208
URLView the original
Language英語
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chongqing University of Posts and Telecommunications
2.Universidade de Macau
Recommended Citation
GB/T 7714
Tian Y.,Ding Z.,Tam K.Y.,et al. Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease[J]. ADMET and DMPK,2015,3(3):274-280.
APA Tian Y..,Ding Z..,Tam K.Y..,Wang Z..,Zhang H..,...&Zheng S..(2015).Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease.ADMET and DMPK,3(3),274-280.
MLA Tian Y.,et al."Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease".ADMET and DMPK 3.3(2015):274-280.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tian Y.]'s Articles
[Ding Z.]'s Articles
[Tam K.Y.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tian Y.]'s Articles
[Ding Z.]'s Articles
[Tam K.Y.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tian Y.]'s Articles
[Ding Z.]'s Articles
[Tam K.Y.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.