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Use of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009
Xiang Y.-T.8; Wang C.-Y.4; Si T.-M.12; Lee E.H.M.8; He Y.-L.13; Ungvari G.S.14; Chiu H.F.K.8; Yang S.-Y.5; Chong M.-Y.7; Tan C.-H.6; Kua E.-H.6; Fujii S.2; Sim K.10; Yong K.H.10; Trivedi J.K.9; Chung E.-K.1; Udomratn P.16; Chee K.-Y.3; Sartorius N.11; Shinfuku N.15
Source PublicationPharmacopsychiatry
ISSN01763679 14390795
AbstractObjective: The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates. Method: A total of 6761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones. Conclusions: The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice. © Georg Thieme Verlag KG Stuttgart - New York.
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Seoul Children's Hospital
2.Hyogo Institute for Traumatic Stress
3.Kuala Lumpur Hospital
4.Beijing An Ding Hospital, Capital Medical University
5.Taipei City Hospital Taiwan
6.National University of Singapore
7.Chang Gung University
8.Chinese University of Hong Kong
9.Chhatrapati Shahuji Maharaj Medical University
10.Singapore Institute of Mental Health
11.Université de Genève
12.Peking University
13.Shanghai Mental Health Center
14.University of Notre Dame Australia
15.Seinan Gakuin University
16.Prince of Songkla University
Recommended Citation
GB/T 7714
Xiang Y.-T.,Wang C.-Y.,Si T.-M.,et al. Use of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009[J]. Pharmacopsychiatry,2011,44(3):114-118.
APA Xiang Y.-T..,Wang C.-Y..,Si T.-M..,Lee E.H.M..,He Y.-L..,...&Shinfuku N..(2011).Use of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009.Pharmacopsychiatry,44(3),114-118.
MLA Xiang Y.-T.,et al."Use of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009".Pharmacopsychiatry 44.3(2011):114-118.
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