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Demographic and clinical features and prescribing patterns of psychotropic medications in patients with the melancholic subtype of major depressive disorder in China
Xiang Y.-T.8; Wang G.3; Hu C.3; Guo T.3; Ungvari G.S.17; Kilbourne A.M.1; Lai K.Y.C.8; Si T.-M.12; Zheng Q.-W.10; Chen D.-F.10; Fang Y.-R.9; Lu Z.16; Yang H.-C.2; Hu J.5; Chen Z.-Y.4; Huang Y.14; Sun J.6; Wang X.-P.15; Li H.-C.11; Zhang J.-B.13; Chiu H.F.K.8
2012-06-29
Source PublicationPLoS ONE
ISSN19326203
Volume7Issue:6
AbstractBackground: Little has been known about the demographic and clinical features of the melancholic subtype of major depressive disorder (MDD) in Chinese patients. This study examined the frequency of melancholia in Chinese MDD patients and explored its demographic and clinical correlates and prescribing patterns of psychotropic drugs. Methods: A consecutively collected sample of 1,178 patients with MDD were examined in 13 psychiatric hospitals or psychiatric units of general hospitals in China nationwide. The cross-sectional data of patients' demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. The diagnosis of the melancholic subtype was established using the Mini International Neuropsychiatric Interview (MINI). Medications ascertained included antidepressants, mood stabilizers, antipsychotics and benzodiazepines. Results: Six hundred and twenty nine (53.4%) of the 1,178 patients fulfilled criteria for melancholia. In multiple logistic regression analyses, compared to non-melancholic counterparts, melancholic MDD patients were more likely to be male and receive benzodiazepines, had more frequent suicide ideations and attempts and seasonal depressive episodes, while they were less likely to be employed and receive antidepressants and had less family history of psychiatric disorders and lifetime depressive episodes. Conclusions: The demographic and clinical features of melancholic MDD in Chinese patients were not entirely consistent with those found in Western populations. Compared to non-melancholic MDD patients, melancholic patients presented with different demographic and clinical features, which have implications for treatment decisions. © 2012 Xiang et al.
DOI10.1371/journal.pone.0039840
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Veterans Administration Ann Arbor Center for Clinical Management Research
2.Shenzhen Mental Health Centre
3.Beijing An Ding Hospital, Capital Medical University
4.Hangzhou Seventh People's Hospital
5.Harbin Medical University
6.Nanjing Medical University
7.University of Michigan Medical School
8.Chinese University of Hong Kong
9.Shanghai Jiao Tong University School of Medicine
10.Peking University Health Science Center
11.Zhejiang University
12.Peking University
13.Sun Yat-Sen University
14.West China Hospital of Sichuan University
15.Second Xiangya Hospital of Central-South University
16.Tongji University
17.University of Notre Dame Australia
Recommended Citation
GB/T 7714
Xiang Y.-T.,Wang G.,Hu C.,et al. Demographic and clinical features and prescribing patterns of psychotropic medications in patients with the melancholic subtype of major depressive disorder in China[J]. PLoS ONE,2012,7(6).
APA Xiang Y.-T..,Wang G..,Hu C..,Guo T..,Ungvari G.S..,...&Chiu H.F.K..(2012).Demographic and clinical features and prescribing patterns of psychotropic medications in patients with the melancholic subtype of major depressive disorder in China.PLoS ONE,7(6).
MLA Xiang Y.-T.,et al."Demographic and clinical features and prescribing patterns of psychotropic medications in patients with the melancholic subtype of major depressive disorder in China".PLoS ONE 7.6(2012).
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