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Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)
Xiang Y.-T.12; Kreyenbuhl J.7; Dickerson F.B.1; Ungvari G.S.9; Wang C.-Y.6; Si T.-M.15; Lee E.H.M.12; Chiu H.F.K.12; Lai K.Y.C.12; He Y.-L.16; Yang S.-Y.8; Chong M.-Y.11; Tan C.-H.10; Kua E.-H.10; Fujii S.3; Sim K.14; Yong M.K.H.14; Trivedi J.K.13; Chung E.-K.2; Udomratn P.19; Chee K.-Y.5; Sartorius N.4; Shinfuku N.18
2012-07-01
Source PublicationInternational Journal of Clinical Pharmacology and Therapeutics
ISSN09461965
Volume50Issue:7Pages:500-504
AbstractObjective: This study surveyed the prescribing patterns of antipsychotic medications in Asian older schizophrenia patients with extrapyramidal side effects (EPS) during the period between 2001 and 2009. Method: Information on 848 hospitalized patients with schizophrenia aged 60 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001 - 2009). Data from those patients with reported EPS from 8 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India and Malaysia were analyzed. The cross-sectional data of socio-demographic and clinical characteristics and antipsychotic prescriptions were collected using a standardized protocol and data collection procedure. Results: Of the 309/848 (36%) patients suffering from EPS, 210 patients (210/309; 68.0%) received at least one type of first generation antipsychotic (FGA), and 99 (99/309; 32.0%) received second generation antipsychotics (SGAs) only. Of SGAs prescribed in patients with EPS, risperidone was the most commonly used (100/309; 32.4%) followed by olanzapine (33/309; 10.7%) and quetiapine (25/309; 8.1%). Conclusions: FGAs were frequently used in Asian older schizophrenia patients with EPS. Considering the potential adverse effects of FGAs on existing EPS, the reasons for the frequent use of FGAs need to be urgently identified. ©2012 Dustri-Verlag Dr. K. Feistle.
KeywordExtrapyramidal side effects Older patients Prescription patterns Schizophrenia
DOI10.5414/CP201683
URLView the original
Language英語
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The Stanley Research Program at Sheppard Pratt
2.National Seoul Hospital
3.Hyogo Institute for Traumatic Stress (HITS)
4.Association for the Improvement of Mental Health Programs
5.Kuala Lumpur Hospital
6.Beijing An Ding Hospital, Capital Medical University
7.University of Maryland School of Medicine
8.Taipei City Hospital Taiwan
9.University of Western Australia
10.National University of Singapore
11.Chang Gung University
12.Chinese University of Hong Kong
13.Chhatrapati Shahuji Maharaj Medical University
14.Singapore Institute of Mental Health
15.Peking University
16.Shanghai Mental Health Center
17.Veterans Administration
18.Seinan Gakuin University
19.Prince of Songkla University
Recommended Citation
GB/T 7714
Xiang Y.-T.,Kreyenbuhl J.,Dickerson F.B.,et al. Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)[J]. International Journal of Clinical Pharmacology and Therapeutics,2012,50(7):500-504.
APA Xiang Y.-T..,Kreyenbuhl J..,Dickerson F.B..,Ungvari G.S..,Wang C.-Y..,...&Shinfuku N..(2012).Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009).International Journal of Clinical Pharmacology and Therapeutics,50(7),500-504.
MLA Xiang Y.-T.,et al."Antipsychotic treatment in older schizophrenia patients with extrapyramidal side effects in Asia (2001-2009)".International Journal of Clinical Pharmacology and Therapeutics 50.7(2012):500-504.
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