UM  > 健康科學學院
Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)
Xiang Y.-T.13; Kreyenbuhl J.9; Dickerson F.B.2; Ungvari G.S.11; Wang C.-Y.8; Si T.-M.15; Lee E.H.13; He Y.-L.16; Chiu H.F.13; Yang S.-Y.10; Chong M.-Y.12; Tan C.-H.1; Kua E.-H.1; Fujii S.5; Sim K.4; Yong M.K.4; Trivedi J.K.14; Chung E.-K.3; Udomratn P.19; Chee K.-Y.7; Sartorius N.6; Shinfuku N.18
2012-12-01
Source PublicationAustralian and New Zealand Journal of Psychiatry
ISSN00048674 14401614
Volume46Issue:12Pages:1159-1164
AbstractObjective: This study examined the prescribing patterns of several first- (FGAs) and second generation antipsychotic (SGAs) medications administered to older Asian patients with schizophrenia during the period between 2001 and 2009. Method: Information on hospitalized patients with schizophrenia aged 65 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (20012009). There were no older patients in Thailand, therefore data on 467 patients in eight Asian countries and territories including China, Hong Kong SAR, India, Japan, Korea, Malaysia, Singapore, and Taiwan were analysed. Cross-sectional socio-demographic data, clinical characteristics and antipsychotic prescriptions were assessed using a standardized protocol and data collection procedure. Results: Of the 467 patients, 192 patients (41.1%) received FGAs only, 166 (35.5%) received SGAs only and 109 (23.3%) received a combination of FGAs and SGAs. Of the FGAs, haloperidol was the most commonly used (31.3%; mean 9.4 ± 6.7 mg/day), followed by chlorpromazine (15.4%; mean 126.4 ± 156.4 mg/day) and sulpiride (6.6%; mean 375.0 ± 287.0 mg/day). Of the SGAs, risperidone was the most commonly used (31.5%; mean 4.5 ± 2.7 mg/day), followed by olanzapine (13.1%; mean 13.6 ± 6.5 mg/day), quetiapine (7.3%; mean 325.0 ± 237.3 mg/day) and aripiprazole (1.9%; mean 17.6 ± 7.7 mg/day). Conclusions: FGAs and higher doses of certain SGAs (risperidone, olanzapine and quetiapine) were still commonly dispensed to older Asian patients with schizophrenia. Considering older patients reduced tolerability of potentially severe side effects associated with FGAs and higher doses of certain SGAs, continuing education and training addressing the rational use of antipsychotics in this population is clearly needed. © 2012 The Royal Australian and New Zealand College of Psychiatrists.
KeywordAsia older patients prescription patterns schizophrenia
DOI10.1177/0004867412453625
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National University of Singapore
2.The Stanley Research Program at Sheppard Pratt
3.National Seoul Hospital
4.Institute of Mental Health
5.Hyogo Institute for Traumatic Stress (HITS)
6.Association for the Improvement of Mental Health Programs
7.Kuala Lumpur Hospital
8.Beijing An Ding Hospital, Capital Medical University
9.University of Maryland School of Medicine
10.Taipei City Hospital Taiwan
11.University of Western Australia
12.Chang Gung University
13.Chinese University of Hong Kong
14.Chhatrapati Shahuji Maharaj Medical University
15.Peking University
16.Shanghai Mental Health Center
17.Veterans Administration
18.Seinan Gakuin University
19.Prince of Songkla University
Recommended Citation
GB/T 7714
Xiang Y.-T.,Kreyenbuhl J.,Dickerson F.B.,et al. Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)[J]. Australian and New Zealand Journal of Psychiatry,2012,46(12):1159-1164.
APA Xiang Y.-T..,Kreyenbuhl J..,Dickerson F.B..,Ungvari G.S..,Wang C.-Y..,...&Shinfuku N..(2012).Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009).Australian and New Zealand Journal of Psychiatry,46(12),1159-1164.
MLA Xiang Y.-T.,et al."Use of first- and second-generation antipsychotic medications in older patients with schizophrenia in Asia (2001-2009)".Australian and New Zealand Journal of Psychiatry 46.12(2012):1159-1164.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiang Y.-T.]'s Articles
[Kreyenbuhl J.]'s Articles
[Dickerson F.B.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiang Y.-T.]'s Articles
[Kreyenbuhl J.]'s Articles
[Dickerson F.B.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiang Y.-T.]'s Articles
[Kreyenbuhl J.]'s Articles
[Dickerson F.B.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.