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Screening for bipolar disorder with the Mood Disorders Questionnaire in patients diagnosed as major depressive disorder - The experience in China
Hu C.4; Xiang Y.-T.10; Wang G.4; Ungvari G.S.9; Dickerson F.B.2; Kilbourne A.M.1; Lai K.Y.C.10; Si T.-M.13; Fang Y.-R.11; Lu Z.17; Yang H.-C.3; Hu J.6; Chen Z.-Y.5; Huang Y.15; Sun J.7; Wang X.-P.16; Li H.-C.12; Zhang J.-B.14; Chiu H.F.K.10
2012-12-01
Source PublicationJournal of Affective Disorders
ISSN01650327 15732517
Volume141Issue:1Pages:40-46
AbstractBackground: Bipolar disorder (BD) is often misdiagnosed as a major depressive disorder (MDD). This study aimed to test the usefulness of the screening tool, the Mood Disorders Questionnaire (MDQ), to identify BD patients misdiagnosed as MDD in Chinese clinical settings. Methods: A total of 1487 patients treated for MDD were consecutively examined in 13 mental health centers in China. The patients' socio-demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. The MDQ was completed by patients to identify symptoms characteristic of BD. DSM-IV diagnoses were established using the Mini International Neuropsychiatric Interview (MINI). Results: Three hundred-nine of the 1487 patients (20.8%) satisfied DSM-IV criteria for BD; 118 (7.9%) for BD-I and 191 (12.8%) for BD-II on the MINI. The optimal cut-off point on the MDQ to differentiate BD from MDD was 3, while cut-off points of 5 and 3 differentiated BD-I and BD-II from MDD, respectively. The maximum sensitivity was 0.31, 0.45 and 0.22 for differentiating BD, BD-I and BD-II from MDD, respectively. Conclusions: The optimal cutoff points of the MDQ for screening BD in Chinese patients originally diagnosed as MDD were considerably lower than those in earlier studies. The routine clinical use of the MDQ as a screening scale for BD in Chinese patients treated for MDD does not seem to be justified. © 2012 Elsevier B.V.
KeywordBipolar disorder Diagnostic criteria Major depressive disorder Screening
DOI10.1016/j.jad.2012.02.035
URLView the original
Language英語
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Veterans Administration Ann Arbor Center for Clinical Management Research
2.The Stanley Research Program at Sheppard Pratt
3.Shenzhen Mental Health Centre
4.Beijing An Ding Hospital, Capital Medical University
5.Hangzhou Seventh People's Hospital
6.Harbin Medical University
7.Nanjing Medical University
8.University of Michigan Medical School
9.University of Western Australia
10.Chinese University of Hong Kong
11.Shanghai Jiao Tong University School of Medicine
12.Zhejiang University
13.Peking University
14.Sun Yat-Sen University
15.West China Hospital of Sichuan University
16.Second Xiangya Hospital of Central-South University
17.Tongji University
Recommended Citation
GB/T 7714
Hu C.,Xiang Y.-T.,Wang G.,et al. Screening for bipolar disorder with the Mood Disorders Questionnaire in patients diagnosed as major depressive disorder - The experience in China[J]. Journal of Affective Disorders,2012,141(1):40-46.
APA Hu C..,Xiang Y.-T..,Wang G..,Ungvari G.S..,Dickerson F.B..,...&Chiu H.F.K..(2012).Screening for bipolar disorder with the Mood Disorders Questionnaire in patients diagnosed as major depressive disorder - The experience in China.Journal of Affective Disorders,141(1),40-46.
MLA Hu C.,et al."Screening for bipolar disorder with the Mood Disorders Questionnaire in patients diagnosed as major depressive disorder - The experience in China".Journal of Affective Disorders 141.1(2012):40-46.
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