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The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese Population
Zhang X.1; Hui L.1; Liu Y.1; Wang Z.-Q.1; You Y.1; Miao L.-N.1; Sun S.-L.1; Guan S.-L.1; Xiang Y.3; Kosten T.R.2; Zhang X.Y.1
2013
Source PublicationJournal of Clinical Psychiatry
ISSN01606689
Volume74Issue:4
AbstractBackground: Patients with schizophrenia have an increased prevalence of type 2 diabetes mellitus, and type 2 diabetes mellitus has shown an association with the rs4402960 gene polymorphism in the insulin-like growth factor II messenger RNA (mRNA)-binding protein 2 gene (IGF2BP2). We tested this polymorphism and mRNA expression levels of IGF2BP2 for an association in Han Chinese patients with schizophrenia compared to healthy controls. Method: The rs4402960 polymorphism was genotyped in 790 chronic schizophrenic patients (diagnosed according to DSM-IV) and 1,083 unrelated healthy controls in a case-control design. The IGF2BP2 gene expression levels were assayed in 34 patients with chronic schizophrenia and 30 healthy controls by using real-time polymerase chain reaction (PCR). The study was conducted between 2005 and 2007. Results: We found significant differences in the rs4402960 genotype (X 22 = 7.316, P = .026) and allele (X2 1 = 7.056, P = .008) distributions between the patient and control groups. The rs4402960 T allelic frequency was significantly higher in male schizophrenic patients than male controls (28.9% vs 23.5%; P = .004) but not in female patients compared to female controls (27.1% vs 25.5%; P = .498). When real-time PCR was used, the IGF2BP2 gene's isoform B expression levels were significantly greater in schizophrenia than controls (P = .0008). Conclusions: These results suggest that the IGF2BP2 gene may play a role in susceptibility to schizophrenia, supporting the hypothesis that the co-occurrence of type 2 diabetes mellitus and schizophrenia may be explained by shared genetic risk variants. However, this finding remains preliminary since this association has yet to be replicated. © Copyright 2013 Physicians Postgraduate Press, Inc.
DOI10.4088/JCP.12m07846
URLView the original
Language英語
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Jilin University
2.Baylor College of Medicine
3.Chinese University of Hong Kong
Recommended Citation
GB/T 7714
Zhang X.,Hui L.,Liu Y.,et al. The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese Population[J]. Journal of Clinical Psychiatry,2013,74(4).
APA Zhang X..,Hui L..,Liu Y..,Wang Z.-Q..,You Y..,...&Zhang X.Y..(2013).The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese Population.Journal of Clinical Psychiatry,74(4).
MLA Zhang X.,et al."The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese Population".Journal of Clinical Psychiatry 74.4(2013).
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