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Common use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009
Xiang Y.-T.13; Dickerson F.1; Kreyenbuhl J.7; Ungvari G.S.10; Wang C.-Y.6; Si T.-M.15; Lee E.H.M.13; Chiu H.F.K.13; Lai K.Y.C.13; He Y.-L.16; Yang S.-Y.8; Chong M.-Y.12; Tan C.-H.11; Kua E.-H.11; Fujii S.3; Sim K.2; Yong M.K.H.2; Trivedi J.K.14; Chung E.-K.9; Udomratn P.19; Chee K.-Y.5; Sartorius N.4; Shinfuku N.18
2013-03-01
Source PublicationInternational Journal of Geriatric Psychiatry
ISSN08856230 10991166
Volume28Issue:3Pages:305-311
AbstractObjective This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates. Method A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients' socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure. Results The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications. Conclusions Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. © 2012 John Wiley & Sons, Ltd.
Keywordanticholinergic Asia older patients prescription patterns schizophrenia
DOI10.1002/gps.3827
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The Stanley Research Program at Sheppard Pratt
2.Institute of Mental Health
3.Hyogo Institute for Traumatic Stress (HITS)
4.Association for the Improvement of Mental Health Programs
5.Kuala Lumpur Hospital
6.Beijing An Ding Hospital, Capital Medical University
7.University of Maryland School of Medicine
8.Taipei City Hospital Taiwan
9.Seoul National University
10.University of Western Australia
11.National University of Singapore
12.Chang Gung University
13.Chinese University of Hong Kong
14.Chhatrapati Shahuji Maharaj Medical University
15.Peking University
16.Shanghai Mental Health Center
17.VA Medical Center
18.Seinan Gakuin University
19.Prince of Songkla University
Recommended Citation
GB/T 7714
Xiang Y.-T.,Dickerson F.,Kreyenbuhl J.,et al. Common use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009[J]. International Journal of Geriatric Psychiatry,2013,28(3):305-311.
APA Xiang Y.-T..,Dickerson F..,Kreyenbuhl J..,Ungvari G.S..,Wang C.-Y..,...&Shinfuku N..(2013).Common use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009.International Journal of Geriatric Psychiatry,28(3),305-311.
MLA Xiang Y.-T.,et al."Common use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009".International Journal of Geriatric Psychiatry 28.3(2013):305-311.
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