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Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009
Xiang Y.-T.11; Buchanan R.W.7; Ungvari G.S.9; Chiu H.F.K.11; Lai K.Y.C.11; Li Y.-H.14; Si T.-M.14; Wang C.-Y.6; Lee E.H.M.10; He Y.-L.17; Yang S.-Y.8; Chong M.-Y.16; Kua E.-H.1; Fujii S.3; Sim K.13; Yong M.K.H.15; Trivedi J.K.12; Chung E.-K.2; Udomratn P.20; Chee K.-Y.5; Sartorius N.4; Tan C.-H.1; Shinfuku N.19
Source PublicationPLoS ONE
AbstractBackground:To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009.Method:Information on 1,157 hospitalized patients with schizophrenia aged 50 or older in five East Asian countries and territories (China, Hong Kong, Korea, Singapore and Taiwan) was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) project. Socio-demographic and clinical characteristics and prescription of psychotropic medications were recorded.Results:Clozapine was prescribed for 20.6% of the pooled sample; 19.0% in 2001, 19.4% in 2004 and 22.9% in 2009. Multiple logistic regression analysis of the whole sample revealed that patients taking clozapine had a longer duration of illness, more negative symptoms and were less likely to receive first generation antipsychotic and anticholinergic drugs, but more likely to report weight gain compared to those not receiving clozapine. Compared to those in other sites, older patients in China were more likely to receive clozapine.Conclusions:The prescription of clozapine for older Asian schizophrenia inpatients has remained at a stable level during the past decade. The appropriateness of use of clozapine in China needs to be further explored. © 2013 Xiang et al.
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National University of Singapore
2.National Seoul Hospital
3.Hyogo Institute for Traumatic Stress (HITS)
4.Association for the Improvement of Mental Health Programs
5.Kuala Lumpur Hospital
6.Beijing An Ding Hospital, Capital Medical University
7.University of Maryland School of Medicine
8.Taipei City Hospital Taiwan
9.University of Western Australia
10.The University of Hong Kong
11.Chinese University of Hong Kong
12.Chhatrapati Shahuji Maharaj Medical University
13.Singapore Institute of Mental Health
14.Peking University
15.Alexandra Hospital, Singapore
16.Chang Gung University College of Medicine
17.Shanghai Mental Health Center
18.University of Notre Dame Australia
19.Seinan Gakuin University
20.Prince of Songkla University
Recommended Citation
GB/T 7714
Xiang Y.-T.,Buchanan R.W.,Ungvari G.S.,et al. Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009[J]. PLoS ONE,2013,8(6).
APA Xiang Y.-T..,Buchanan R.W..,Ungvari G.S..,Chiu H.F.K..,Lai K.Y.C..,...&Shinfuku N..(2013).Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009.PLoS ONE,8(6).
MLA Xiang Y.-T.,et al."Use of Clozapine in Older Asian Patients with Schizophrenia between 2001 and 2009".PLoS ONE 8.6(2013).
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