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Long-term benzodiazepine use in patients with major depressive disorder in China
Li Y.-H.12; Xiang Y.-T.8; Su Y.-A.12; Shu L.12; Yu X.12; Kilbourne A.M.9; Ungvari G.S.15; Chiu H.F.K.11; Ma C.7; Wang G.-H.16; Bai P.-S.13; Liu X.-H.14; Sun L.-Z.4; Shi J.-G.6; Chen X.-S.2; Mei Q.-Y.3; Li K.-Q.5; Si T.-M.12
Source PublicationPerspectives in Psychiatric Care
ISSN17446163 00315990

Purpose: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD. Design and Methods: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form. Findings: A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors). Practice Implications: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use. © 2013 Wiley Periodicals, Inc.

KeywordBenzodiazepines China Major Depressive Disorder Prescribing Patterns
URLView the original
Indexed BySCI
WOS Research AreaNursing ; Psychiatry
WOS SubjectNursing ; Psychiatry
WOS IDWOS:000339274900002
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Veterans Administration Ann Arbor Center for Clinical Management Research
2.Jiangxi Psychiatric Hospital
3.Suzhou Guangji Hospital
4.Neuropsychiatric Hospital
5.Hebei Mental Health Center
6.Mental Health Center
7.Guangzhou Psychiatric Hospital
8.Beijing An Ding Hospital, Capital Medical University
9.University of Michigan Medical School
10.University of Western Australia
11.Chinese University of Hong Kong
12.Peking University
13.Shanxi Medical University
14.West China Hospital of Sichuan University
15.University of Notre Dame Australia
16.Hubei General Hospital
Recommended Citation
GB/T 7714
Li Y.-H.,Xiang Y.-T.,Su Y.-A.,et al. Long-term benzodiazepine use in patients with major depressive disorder in China[J]. Perspectives in Psychiatric Care,2014,50(3):149-154.
APA Li Y.-H..,Xiang Y.-T..,Su Y.-A..,Shu L..,Yu X..,...&Si T.-M..(2014).Long-term benzodiazepine use in patients with major depressive disorder in China.Perspectives in Psychiatric Care,50(3),149-154.
MLA Li Y.-H.,et al."Long-term benzodiazepine use in patients with major depressive disorder in China".Perspectives in Psychiatric Care 50.3(2014):149-154.
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