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The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii
Wang H.-L.1; Xiang Y.-T.8; Li Q.-Y.1; Wang X.-P.1; Liu Z.-C.1; Hao S.-S.1; Liu X.1; Liu L.-L.1; Wang G.-H.1; Wang D.-G.3; Zhang P.-A.1; Bao A.-Y.1; Chiu H.F.K.6; Ungvari G.S.5; Lai K.Y.C.6; Buchanan R.W.4
2014
Source PublicationJournal of Psychiatric Research
ISSN18791379 00223956
Volume53Issue:1Pages:119-124
Abstract

The objective was to evaluate the efficacy and safety of add-on artemether in first-episode, untreated people with schizophrenia, who were Toxoplasma gondii seropositive, and explore the change in T.gondii antibodies during treatment. In this eight-week, double-blind, randomized, placebo-controlled trial, 100 T.gondii seropositive participants with schizophrenia were randomized to either the artemether or placebo group. Participants in the artemether group received 80mg artemether once per day during the second week (days 8-14) and the fourth week (days 22-28). Participants in the placebo group received identical looking placebo capsules. Psychopathology, adverse side effects and cognitive function were measured using standardized instruments. The group×time interaction effects for the scores of the Positive and Negative Syndrome Scale (PANSS) subscales and performances on all cognitive components were not significant, only the main effect of group was significant. Compared to the placebo group, artemether group participants showed significantly greater reduction in the PANSS negative symptom scale (F=4.7, p=0.03) and the Clinical Global Impressions Scale (F=6.2, p=0.01) scores, but there were no significant differences in the PANSS positive symptom and general psychopathology scales (p>0.05). There were also no significant differences between the two groups in performance on any of the Brief Assessment of Cognition in Schizophrenia (BACS) cognitive domains. The artemether-risperidone combination is safe and well tolerated, but artemether as an adjunct to risperidone does not appear to alleviate cognitive deficits of schizophrenia. TRC-13003145. © 2014 Elsevier Ltd.

KeywordArtemether Cognition Psychopathology Schizophrenia Toxoplasma Gondii
DOI10.1016/j.jpsychires.2014.02.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000335104200018
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hubei General Hospital
2.Hubei Institute of Neurology and Psychiatry Research
3.MaoJian Hospital of Shiyan
4.University of Maryland School of Medicine
5.University of Western Australia
6.Chinese University of Hong Kong
7.University of Notre Dame Australia
8.Universidade de Macau
Recommended Citation
GB/T 7714
Wang H.-L.,Xiang Y.-T.,Li Q.-Y.,et al. The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii[J]. Journal of Psychiatric Research,2014,53(1):119-124.
APA Wang H.-L..,Xiang Y.-T..,Li Q.-Y..,Wang X.-P..,Liu Z.-C..,...&Buchanan R.W..(2014).The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii.Journal of Psychiatric Research,53(1),119-124.
MLA Wang H.-L.,et al."The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii".Journal of Psychiatric Research 53.1(2014):119-124.
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