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A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders
Zu S.3; Xiang Y.-T.3; Liu J.3; Zhang L.3; Wang G.3; Ma X.3; Kilbourne A.M.4; Ungvari G.S.5; Chiu H.F.K.1; Lai K.Y.C.1; Wong S.Y.S.1; Yu D.S.F.1; Li Z.-J.3
2014
Source PublicationJournal of Affective Disorders
ISSN01650327 15732517
Volume152-154Issue:1Pages:262-267
Abstract

Background No study has examined the effect of cognitive-behavioral therapy (CBT) on moderate-severe major depressive disorders (MDD) in China. The objective of this study was to evaluate the effect of CBT, antidepressants alone (MED), combined CBT and antidepressants (COMB) and standard treatment (ST; i.e.; receiving psycho-educational intervention and/or medication treatment determined by treating psychiatrists) on depressive symptoms and social functioning in Chinese patients with moderate-severe MDD. Method A total of 180 patients diagnosed with MDD according to ICD-10 were randomly allocated to one of the four treatment regimens for a period of 6 months. Depressive symptoms were measured using the Hamilton Rating Scale for Depression (HAMD) and the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR). Remission threshold was defined as a C-QIDS-SR total score of <5. Social functioning was evaluated with the Work and Social Adjustment Scale (WSAS). All outcome measures were evaluated at entry, and at 3- and 6-months follow-up. Results At the 6-months assessment, the remission rates in the whole sample (n=96), the MED, the CBT, the COMB and the ST groups were 54.2%, 48%, 75%, 53.5% and 50%, respectively. Following the treatment periods, there was no significant difference in any of the study outcomes between the four groups. However, the CBT showed the greatest effect in the HAMD total score with the effect size=0.94, whereas the ST has only a moderate effect size in the WSAS total score (effect size=0.47). Conclusions The findings support the feasibility and effectiveness of CBT as a psychosocial intervention for Chinese patients with moderate-severe MDD. We also found that single treatment using MED or CBT performed equally well as the combined CBT-antidepressant treatment in controlling the remission. The study provided important knowledge to inform the mental health care planning in China. © 2013 Elsevier B.V.

KeywordChina Cognitive-behavioral Therapy Major Depressive Disorders Outpatients
DOI10.1016/j.jad.2013.09.022
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000327763600035
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Chinese University of Hong Kong
2.Veterans Administration Ann Arbor Center for Clinical Management Research
3.Beijing An Ding Hospital, Capital Medical University
4.University of Michigan Medical School
5.University of Western Australia
6.University of Notre Dame Australia
Recommended Citation
GB/T 7714
Zu S.,Xiang Y.-T.,Liu J.,et al. A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders[J]. Journal of Affective Disorders,2014,152-154(1):262-267.
APA Zu S..,Xiang Y.-T..,Liu J..,Zhang L..,Wang G..,...&Li Z.-J..(2014).A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders.Journal of Affective Disorders,152-154(1),262-267.
MLA Zu S.,et al."A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders".Journal of Affective Disorders 152-154.1(2014):262-267.
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