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The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke
Shi Y.-Z.10; Xiang Y.-T.11; Wu S.-L.10; Zhang N.10; Zhou J.6; Bai Y.1; Wang S.10; Wang Y.-L.10; Zhao X.-Q.10; Ungvari G.S.4; Chiu H.F.K.5; Wang Y.-J.10; Wang C.-X.10
2014-07-08
Source PublicationPLoS ONE
ISSN19326203
Volume9Issue:7
Abstract

Background and Purpose: Most studies on post-stroke depression (PSD) have focused on a certain time point after stroke instead of the time course of PSD. The aim of this study was to determine the relationship between frontal lobe lesions, course of PSD over a year following the stroke onset, and the 1-year prognosis in patients with first-ever ischemic stroke. Methods: A total of 1067 patients from the prospective cohort study on the incidence and outcome of patients with post stroke depression in China who were diagnosed with first-ever ischemic stroke and attended 4 follow-up visits at 14±2 days, 3 months, 6 months, and 1 year after stroke onset, were enrolled in the study. PSD was diagnosed according to DSM-IV. The course of PSD was divided into the following two categories: persistent/recurrent depression and no/transient depression. Patients with any ischemic lesion responsible for the indexed stroke event located in the frontal lobe were defined as patients with frontal lobe lesions. Modified Rankin Scale (mRS) ≥2 at 1-year was considered to be poor prognosis. Results: There were 109 patients with and 958 patients without frontal lobe lesions that formed the frontal lobe (FL) and no-frontal lobe (NFL) groups, respectively. After adjusting for confounding variables, frontal lobe lesion was significantly associated with persistent/recurrent PSD (OR 2.025, 95%CI 1.039-3.949). Overall, 32.7% of patients in the FL group had poor prognosis at 1-year compared with 22.7% in the NFL group (P = 0.021). Compared with no/transient depression, persistent/recurrent depression was found to be an independent predictor of poor prognosis at 1-year both in FL and NFL groups. Conclusions: Long-term and periodical screening, evaluation and treatment are needed for PSD after the onset of ischemic stroke, particularly for patients with frontal lobe infarction. © 2014 Shi et al.

DOI10.1371/journal.pone.0100456
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000339242700009
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Xinjiang Production and Construction Corps 13 division Red Star Hospital
2.Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease
3.Beijing An Ding Hospital, Capital Medical University
4.University of Western Australia
5.Chinese University of Hong Kong
6.Capital Medical University China
7.Capital Medical University, Beijing Institute For Brain Disorders
8.China National Clinical Research Center for Neurological Diseases
9.University of Notre Dame Australia
10.Beijing Tiantan Hospital
11.Universidade de Macau
Recommended Citation
GB/T 7714
Shi Y.-Z.,Xiang Y.-T.,Wu S.-L.,et al. The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke[J]. PLoS ONE,2014,9(7).
APA Shi Y.-Z..,Xiang Y.-T..,Wu S.-L..,Zhang N..,Zhou J..,...&Wang C.-X..(2014).The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke.PLoS ONE,9(7).
MLA Shi Y.-Z.,et al."The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke".PLoS ONE 9.7(2014).
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