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Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012
Wang Y.-X.10; Xiang Y.-T.15; Su Y.-A.10; Li Q.10; Shu L.10; Ng C.H.7; Ungvari G.S.13; Chiu H.F.K.9; Nin Y.-P.6; Wang G.-H.14; Bai P.-S.11; Li T.12; Sun L.-Z.4; Shi J.-G.1; Chen X.-S.2; Mei Q.-Y.3; Li K.-Q.5; Yu X.10; Si T.-M.10
2015
Source PublicationChinese Medical Journal
ISSN03666999
Volume128Issue:14Pages:1847-1852
Abstract

Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL). Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients’ socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection. Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P < 0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups. Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients’ and relatives’ satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.

KeywordAntipsychotic Medication Major Depression Prescription Patterns
DOI10.4103/0366-6999.160485
URLView the original
Indexed BySCI
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000358430300001
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Shaanxi Mental Health Center
2.Jiangxi Mental Health Center
3.Suzhou Guangji Hospital
4.Neuropsychiatric Hospital
5.Hebei Mental Health Center
6.Guangzhou Psychiatric Hospital
7.University of Melbourne
8.University of Western Australia
9.Chinese University of Hong Kong
10.Peking University
11.Shanxi Medical University
12.West China Hospital of Sichuan University
13.University of Notre Dame Australia
14.Hubei General Hospital
15.Universidade de Macau
Recommended Citation
GB/T 7714
Wang Y.-X.,Xiang Y.-T.,Su Y.-A.,et al. Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012[J]. Chinese Medical Journal,2015,128(14):1847-1852.
APA Wang Y.-X..,Xiang Y.-T..,Su Y.-A..,Li Q..,Shu L..,...&Si T.-M..(2015).Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012.Chinese Medical Journal,128(14),1847-1852.
MLA Wang Y.-X.,et al."Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012".Chinese Medical Journal 128.14(2015):1847-1852.
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