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Prevalence and prescription of antidepressants in depression with somatic comorbidity in Asia: The research on east Asian psychotropic prescription patterns study
Chen C.9; Si T.-M.9; Xiang Y.-T.14; Ungvari G.S.6; Wang C.-Y.5; He Y.-L.10; Kua E.-H.1; Fujii S.11; Sim K.3; Trivedi J.K.8; Chung E.-K.2; Udomratn P.13; Chee K.-Y.4; Sartorius N.; Tan C.-H.1; Shinfuku N.12
2015
Source PublicationChinese Medical Journal
ISSN03666999
Volume128Issue:7Pages:853-858
Abstract

Background: Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity (SC) in depression and compared the prescriptions of antidepressants in depressed patients with and without SC. Methods: A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10th revision. We listed 17 common chronic somatic diseases. Patients’ socio‑demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure. Results: Of the patients examined, 1240 were diagnosed with depression and 30% of them (n = 375) had SC. The most common comorbid condition was diabetes (23.7%). The patients with SC were more likely to seek help at a general hospital (74.7% vs. 47.2%), and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC (30.4% vs. 22.9%). Conclusions: SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence‑based guidelines for the use of new antidepressants in depressed patients with SC.

KeywordAsia Depression Prescription Prevalence Somatic Comorbidity
DOI10.4103/0366-6999.154272
URLView the original
Indexed BySCI
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000352533500001
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National University of Singapore
2.National Seoul Hospital
3.Institute of Mental Health
4.Kuala Lumpur Hospital
5.Beijing An Ding Hospital, Capital Medical University
6.University of Western Australia
7.Chinese University of Hong Kong
8.Chhatrapati Shahuji Maharaj Medical University
9.Peking University
10.Shanghai Mental Health Center
11.Fukushima Medical University
12.Seinan Gakuin University
13.Prince of Songkla University
14.Universidade de Macau
Recommended Citation
GB/T 7714
Chen C.,Si T.-M.,Xiang Y.-T.,et al. Prevalence and prescription of antidepressants in depression with somatic comorbidity in Asia: The research on east Asian psychotropic prescription patterns study[J]. Chinese Medical Journal,2015,128(7):853-858.
APA Chen C..,Si T.-M..,Xiang Y.-T..,Ungvari G.S..,Wang C.-Y..,...&Shinfuku N..(2015).Prevalence and prescription of antidepressants in depression with somatic comorbidity in Asia: The research on east Asian psychotropic prescription patterns study.Chinese Medical Journal,128(7),853-858.
MLA Chen C.,et al."Prevalence and prescription of antidepressants in depression with somatic comorbidity in Asia: The research on east Asian psychotropic prescription patterns study".Chinese Medical Journal 128.7(2015):853-858.
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