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Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease
Chen Y.-K.1; Xiao W.-M.1; Li W.-Y.1; Liu Y.-L.1; Li W.1; Qu J.-F.1; Fang X.-W.1; Weng H.-Y.1; Ungvari G.S.2; Xiang Y.-T.4
2015-05-01
Source PublicationGeriatrics and Gerontology International
ISSN14470594 14441586
Volume15Issue:5Pages:588-593
Abstract

Objectives: The aim of the present study was to explore the magnetic resonance imaging correlates of the performance of instrumental activities of daily living (IADL) in patients with Alzheimer's disease combined with cerebrovascular disease. Methods: A total of 66 patients with Alzheimer's disease combined with cerebrovascular disease formed the study sample. Two regression models were constructed to find correlates of IADL. Model 1 only included clinical variables and model 2 included both clinical and magnetic resonance imaging variables. Results: In model 1, with IADL as the dependent variable, the Mini-Mental State Examination (MMSE) score, Physical Self-Maintenance Scale score at baseline and age were significant correlates accounting for 40.1% of the variance of IADL at baseline. MMSE score and age were also significant correlates of IADL at 6 months, accounting for 38.1% of the variance of it. In model 2, severity of white matter lesions, MMSE and Physical Self-Maintenance Scale scores at baseline significantly correlated with IADL at baseline, accounting for 52.1% of the variance of the dependent variables; severity of white matter lesions and MMSE significantly correlated with IADL at 6 months, accounting for 41.5% of the variance of the dependent variables. Conclusion: In patients with Alzheimer's disease combined with cerebrovascular disease, subcortical ischemic lesions might be significant contributor to the functional status.

KeywordActivities Of Daily Living Cerebrovascular Disease Dementia Functional Status Magnetic Resonance Imaging
DOI10.1111/ggi.12323
URLView the original
Indexed BySCI
Language英语
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology ; Gerontology
WOS IDWOS:000355732800009
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Dongguan People's Hospital
2.University of Western Australia
3.University of Notre Dame Australia
4.Universidade de Macau
Recommended Citation
GB/T 7714
Chen Y.-K.,Xiao W.-M.,Li W.-Y.,et al. Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease[J]. Geriatrics and Gerontology International,2015,15(5):588-593.
APA Chen Y.-K..,Xiao W.-M..,Li W.-Y..,Liu Y.-L..,Li W..,...&Xiang Y.-T..(2015).Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease.Geriatrics and Gerontology International,15(5),588-593.
MLA Chen Y.-K.,et al."Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease".Geriatrics and Gerontology International 15.5(2015):588-593.
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