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Clozapine Prescription and Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care
Hou C.-L.4; Cai M.-Y.1; Ma X.-R.; Zang Y.; Jia F.-J.4; Lin Y.-Q.4; Chiu H.F.K.5; Ungvari G.S.6; Ng C.H.2; Zhong B.-L.5; Cao X.-L.; Li Y.5; Shinfuku N.7; Xiang Y.-T.8
2015-08-05
Source PublicationPharmacopsychiatry
ISSN14390795 01763679
Volume48Issue:6Pages:200-204
Abstract

Objective: Clozapine is frequently used to treat schizophrenia in China. Maintenance treatment for clinically stable patients with schizophrenia is usually provided by Chinese primary care physicians, but no study has investigated the frequency of its use prescribed by primary care physicians. This study described the frequency, demographic and clinical characteristics of clozapine treatment and its impact on insight and quality of life (QOL) of patients with schizophrenia treated in primary care in China. Method: A total of 623 patients with schizophrenia treated in 22 primary care services in Guangzhou, China in 2013 formed the study sample. Patients' socio-demographic and clinical characteristics including psychopathology, medication side effects and QOL were recorded using a standardized protocol and data collection. Results: The frequency of clozapine prescription was 35.6% with a mean daily dose of 127.7±88.2 mg. There were no significant differences between the patients with and without clozapine in either of the QOL domains after controlling the confounding factors. Multiple logistic regression analyses revealed that patients on clozapine had younger age of onset, more hospitalizations, more severe extrapyramidal side effects, but better insight and fewer prescriptions of first generation antipsychotics. Conclusions: Clozapine use was found to be common and associated with better insight in patients with schizophrenia treated in primary care in China. Further examination of the rationale and appropriateness of clozapine in primary care in China is warranted.

KeywordChina Clozapine Primary Care Schizophrenia
DOI10.1055/s-0035-1555939
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Psychiatry
WOS SubjectPharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000360944600002
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Guangdong Center for Disease Control and Prevention
2.University of Melbourne
3.University of Western Australia
4.Guangdong General Hospital
5.Chinese University of Hong Kong
6.University of Notre Dame Australia
7.Kobe University School of Medicine
8.Universidade de Macau
Recommended Citation
GB/T 7714
Hou C.-L.,Cai M.-Y.,Ma X.-R.,et al. Clozapine Prescription and Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care[J]. Pharmacopsychiatry,2015,48(6):200-204.
APA Hou C.-L..,Cai M.-Y..,Ma X.-R..,Zang Y..,Jia F.-J..,...&Xiang Y.-T..(2015).Clozapine Prescription and Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care.Pharmacopsychiatry,48(6),200-204.
MLA Hou C.-L.,et al."Clozapine Prescription and Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care".Pharmacopsychiatry 48.6(2015):200-204.
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