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A Water-Soluble, Two-Photon Probe for Imaging Endogenous Hypochlorous Acid in Live Tissue
Xing, Panfei1; Feng, Yanxian1; Niu, Yiming1; Li, Qiu1; Zhang, Zhe1; Dong, Lei2; Wang, Chunming1
2018-04-17
Source PublicationCHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
Volume24Issue:22Pages:5748-5753
Abstract

Detection of hypochlorous acid (HClO) in the living system may help to uncover its essential biological functions. However, current imaging agents suffer from poor water solubility that limit their live-tissue applications. Here, a water-soluble probe (NNH) is devised through innovative hydrazone modification of 1,8-naphthalimide at 3 position. NNH was successfully applied to tracking endogenous HClO in both cultured macrophages and a liver injury model in mice. NNH demonstrated remarkably increased water solubility and multiple desirable features including two-photon absorbance, anti-bleaching capability, rapid cellular uptake, and low cytotoxicity. NNH is the first hydrazone-based probe for real-time imaging of HClO in live tissue.

KeywordEndogenous Hypochlorous Acid Fluorescent Probe Live Tissue Two-photon Water-soluble
DOI10.1002/chem.201800249
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000430168500009
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong, Lei; Wang, Chunming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, P. R. China
2.State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Institution, Nanjing, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xing, Panfei,Feng, Yanxian,Niu, Yiming,et al. A Water-Soluble, Two-Photon Probe for Imaging Endogenous Hypochlorous Acid in Live Tissue[J]. CHEMISTRY-A EUROPEAN JOURNAL,2018,24(22):5748-5753.
APA Xing, Panfei.,Feng, Yanxian.,Niu, Yiming.,Li, Qiu.,Zhang, Zhe.,...&Wang, Chunming.(2018).A Water-Soluble, Two-Photon Probe for Imaging Endogenous Hypochlorous Acid in Live Tissue.CHEMISTRY-A EUROPEAN JOURNAL,24(22),5748-5753.
MLA Xing, Panfei,et al."A Water-Soluble, Two-Photon Probe for Imaging Endogenous Hypochlorous Acid in Live Tissue".CHEMISTRY-A EUROPEAN JOURNAL 24.22(2018):5748-5753.
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