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Aripiprazole for Tourette's syndrome: A systematic review and meta-analysis
Zheng W.4; Li X.-B.4; Xiang Y.-Q.4; Zhong B.-L.7; Chiu H.F.K.7; Ungvari G.S.8; Ng C.H.5; Lok G.K.I.3; Xiang Y.-T.1
2016
Source PublicationHuman Psychopharmacology
ISSN10991077 08856222
Volume31Issue:1Pages:11-18
Abstract

Objective To review the efficacy and safety of aripiprazole (ARI) for Tourette's syndrome (TS). Methods This review included randomized controlled trials (RCTs) of children and adolescents (6-18 years) with TS comparing ARI monotherapy with another monotherapies in relation to clinical improvement and adverse events. Results Six RCTs with a total of 528 subjects (ARI treatment group: n = 253; control group: n = 275) met the inclusion criteria. These included two RCTs (n = 255) that compared ARI monotherapy with tiapride (TIA). Tic symptoms control assessed by Yale Global Tic Severity Scale (Standard Mean Difference (SMD) = -0.38 (Confidence Interval (CI) = -1.32 to 0.56); I = 90%, P = 0.42) revealed no significant differences between the two groups. Extrapyramidal symptoms were significantly different when ARI (1.5%) was compared with haloperidol (HAL) (43.5%). No significant group differences were found in the rates of nausea/vomiting, dizziness, and dry mouth between ARI and TIA (RR = 0.57 to 1.00 (95%CI = 0.14-4.20); I = 0% to 69%, P = 0.35 to 1.00). Conclusion This review found that ARI has similar efficacy to TIA and HAL for TS, while extrapyramidal symptoms were significantly less with ARI than with HAL. ARI can be considered as an alternative treatment option for TS.

KeywordAripiprazole Children Rct Tourette's Syndrome
DOI10.1002/hup.2498
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000371915100002
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Universidade de Macau
2.China National Clinical Research Center for Psychiatric Disorders
3.Kiang Wu Nursing College of Macau
4.Beijing An Ding Hospital, Capital Medical University
5.University of Melbourne
6.University of Western Australia
7.Chinese University of Hong Kong
8.University of Notre Dame Australia
Recommended Citation
GB/T 7714
Zheng W.,Li X.-B.,Xiang Y.-Q.,et al. Aripiprazole for Tourette's syndrome: A systematic review and meta-analysis[J]. Human Psychopharmacology,2016,31(1):11-18.
APA Zheng W..,Li X.-B..,Xiang Y.-Q..,Zhong B.-L..,Chiu H.F.K..,...&Xiang Y.-T..(2016).Aripiprazole for Tourette's syndrome: A systematic review and meta-analysis.Human Psychopharmacology,31(1),11-18.
MLA Zheng W.,et al."Aripiprazole for Tourette's syndrome: A systematic review and meta-analysis".Human Psychopharmacology 31.1(2016):11-18.
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