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Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex
Yu P.1; Chen X.1; Zhao W.1; Zhang Z.1; Zhang Q.3; Han B.1; Zhai J.3; Chen M.3; Du B.1; Deng X.1; Ji F.3; Wang C.4; Xiang Y.-T.4; Li D.6; Wu H.2; Li J.1; Dong Q.1; Chen C.5
2016-07-01
Source PublicationHuman Brain Mapping
ISSN10970193 10659471
Volume37Issue:7Pages:2398-2406
Abstract

Recently, a single nucleotide polymorphism (SNP) in the CAMKK2 gene (rs1063843) was found to be associated with lower expression of the gene in the dorsolateral prefrontal cortex (DLPFC) and with schizophrenia (SCZ) and deficits in working memory and executive function. However, the brain mechanism underlying this association is poorly understood. A functional magnetic resonance imaging (fMRI) study (N = 84 healthy volunteers) involving multiple cognitive tasks, including a Stroop task (to measure attentional executive control), an N-back task (to measure working memory), and a delay discounting task (to measure decision making) to identify the brain regions affected by rs1063843 was performed. Across all three tasks, it was found that carriers of the risk allele consistently exhibited increased activation of the left DLPFC. In addition, the risk allele carriers also exhibited increased activation of the right DLPFC and the left cerebellum during the Stroop task and of the left caudate nucleus during the N-back task. These findings helped to elucidate the role of CAMKK2 in cognitive functions and in the etiology of SCZ. Hum Brain Mapp 37:2398–2406, 2016. © 2016 Wiley Periodicals, Inc.

KeywordCamkk2 Cognitive Function Dorsolateral Prefrontal Cortex Functional Magnetic Resonance Imaging Schizophrenia Striatum
DOI10.1002/hbm.23181
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000382488800003
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Beijing Normal University
2.Shengli Petroleum Administration Bureau
3.Jining Medical University
4.Beijing An Ding Hospital, Capital Medical University
5.University of California, Irvine
6.Duke University
7.Universidade de Macau
Recommended Citation
GB/T 7714
Yu P.,Chen X.,Zhao W.,et al. Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex[J]. Human Brain Mapping,2016,37(7):2398-2406.
APA Yu P..,Chen X..,Zhao W..,Zhang Z..,Zhang Q..,...&Chen C..(2016).Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex.Human Brain Mapping,37(7),2398-2406.
MLA Yu P.,et al."Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex".Human Brain Mapping 37.7(2016):2398-2406.
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