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Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis
Zheng W.4; Xiang Y.-Q.1; Li X.-B.1; Ungvari G.S.3; Chiu H.F.K.6; Sun F.7; D'Arcy C.5; Meng X.8; Xiang Y.-T.10
2016-07-01
Source PublicationHuman Psychopharmacology
ISSN10991077 08856222
Pages286-295
Abstract

Objective: The aim of this study was to examine the efficacy of huperzine A (HupA), an isolate of Huperzine serrata, in the treatment of cognitive deficits in schizophrenia spectrum disorders. Methods: PubMed, PsycINFO, Embase, Cochrane Library, Cochrane Controlled Trials Register, WanFang, Chinese Biomedical, and China Journal Net databases were searched from inception to 15 July 2015 for randomized controlled trials (RCTs) in English or Chinese of HupA augmentation of antipsychotic drug therapy versus placebo or ongoing antipsychotic treatment. Results: Twelve RCTs (n = 1117) lasting 11.7 ± 6.0 weeks met inclusion criteria. All had been conducted in China. HupA outperformed comparators on the following outcome measures: the Wechsler Memory Scale-Revised including memory quotient (weighted mean difference (WMD: 10.59; 95% confidence interval (CI): 5.65, 15.53; p < 0.0001); Wechsler Adult Intelligence Scale-Revised including verbal intelligence quotient (IQ), performance IQ, and full IQ (WMD: 3.97 to 5.66; 95%CI: 0.20, 8.58; p = 0.01 to 0.00001); Wisconsin Card Sorting Test including response administer and non-perseverative errors (WMD: −12.79 to −12.29; 95%CI: −23.70, −0.88; p = 0.03 to 0.003). In studies using the Positive and Negative Syndrome Scale (n = 7)/Brief Psychiatric Rating Scale (n = 1), the differences in total score were significant (standard mean difference: −0.77; 95%CI: −1.27, −0.27; p = 0.002). All-cause discontinuation (risk ratio: 0.67; 95%CI: 0.36, 1.24; p = 0.20) and adverse events were similar between groups. Conclusions: This review suggests that adjunctive HupA is an effective choice for improving cognitive function for patients with schizophrenia spectrum disorders. More well-designed RCTs are needed to further confirm HupA's efficacy.

KeywordAntipsychotic Cognitive Function Huperzine a Meta-analysis Schizophrenic-spectrum Disorders Systematic Review
DOI10.1002/hup.2537
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000379939200003
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Clinical Research Center for Geriatric Disorders
2.Beijing An Ding Hospital, Capital Medical University
3.University of Western Australia
4.Guangzhou Medical University
5.University of Saskatchewan
6.Chinese University of Hong Kong
7.Peking University
8.McGill University, Douglas Mental Health University Institute
9.Capital Medical University, Beijing Institute For Brain Disorders
10.Universidade de Macau
Recommended Citation
GB/T 7714
Zheng W.,Xiang Y.-Q.,Li X.-B.,et al. Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis[J]. Human Psychopharmacology,2016:286-295.
APA Zheng W..,Xiang Y.-Q..,Li X.-B..,Ungvari G.S..,Chiu H.F.K..,...&Xiang Y.-T..(2016).Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.Human Psychopharmacology,286-295.
MLA Zheng W.,et al."Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis".Human Psychopharmacology (2016):286-295.
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