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The ANK3 gene and facial affect processing: An ERP study
Zhao W.1; Zhang Q.4; Yu P.1; Zhang Z.1; Chen X.1; Gu H.1; Zhai J.4; Chen M.4; Du B.1; Deng X.1; Ji F.4; Wang C.5; Xiang Y.-T.8; Li D.7; Wu H.3; Dong Q.1; Luo Y.1; Li J.1; Chen C.6
2016-09-01
Source PublicationAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
ISSN1552485X 15524841
Volume171Issue:6Pages:861-866
Abstract

ANK3 is one of the most promising candidate genes for bipolar disorder (BD). A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al., 2003; Kieseppä, 2004; Edvardsen et al., 2008]. Because facial affect processing is disrupted in patients with BD, the current study aimed to explore whether the BD risk alleles are associated with the N170, an early event-related potential (ERP) component related to facial affect processing. We collected data from two independent samples of healthy individuals (Ns = 83 and 82, respectively) to test the association between rs10994336 and an early event-related potential (ERP) component (N170) that is sensitive to facial affect processing. Repeated-measures analysis of covariance in both samples consistently revealed significant main effects of rs10994336 genotype (Sample I: F (1, 72) = 7.24, P = 0.009; Sample II: F (1, 69) = 11.81, P = 0.001), but no significant interaction of genotype × electrodes (Ps > 0.05) or genotype × emotional conditions (Ps > 0.05). These results suggested that rs10994336 was linked to early ERP component reflecting facial structural encoding during facial affect processing. These results shed new light on the brain mechanism of this risk SNP and associated disorders such as BD. © 2016 Wiley Periodicals, Inc.

KeywordAnk3 Event-related Potential Facial Affect Processing N170 Polymorphism
DOI10.1002/ajmg.b.32456
URLView the original
Indexed BySCI
Language英语
WOS Research AreaGenetics & Heredity ; Psychiatry
WOS SubjectGenetics & Heredity ; Psychiatry
WOS IDWOS:000382871600011
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Beijing Normal University
2.Faculty of Health Sciences
3.Shengli Petroleum Administration Bureau
4.Jining Medical University
5.Beijing An Ding Hospital, Capital Medical University
6.University of California, Irvine
7.Duke University
8.Universidade de Macau
Recommended Citation
GB/T 7714
Zhao W.,Zhang Q.,Yu P.,et al. The ANK3 gene and facial affect processing: An ERP study[J]. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics,2016,171(6):861-866.
APA Zhao W..,Zhang Q..,Yu P..,Zhang Z..,Chen X..,...&Chen C..(2016).The ANK3 gene and facial affect processing: An ERP study.American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics,171(6),861-866.
MLA Zhao W.,et al."The ANK3 gene and facial affect processing: An ERP study".American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 171.6(2016):861-866.
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