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Clinical use of mood stabilizers with antidepressants in Asia: Report from the research on asian psychotropic prescription patterns for antidepressants (REAP-AD) projects in 2004 and 2013
Rajaratnam K.1; Xiang Y.-T.22; Tripathi A.13; Chiu H.F.K.12; Si T.-M.16; Chee K.-Y.6; Avasthi A.18; Grover S.18; Chong M.-Y.11; Kuga H.15; Kanba S.15; He Y.-L.17; Lee M.-S.9; Yang S.-Y.8; Udomratn P.21; Kallivayalil R.A.3; Tanra A.J.20; Maramis M.M.10; Shen W.W.14; Sartorius N.4; Kua E.-H.2; Tan C.-H.2; Mahendran R.2; Shinfuku N.19; Sum M.Y.1; Baldessarini R.J.5; Sim K.1
2017-04-01
Source PublicationJournal of Clinical Psychopharmacology
ISSN1533712X 02710749
Volume37Issue:2Pages:255-259
Abstract

Objective As most reports concerning treatment with combinations of mood stabilizer (MS) with antidepressant (AD) drugs are based in the West, we surveyed characteristics of such cotreatment in 42 sites caring for the mentally ill in 10 Asian countries. Methods This cross-sectional, pharmacoepidemiologic study used 2004 and 2013 data from the REAP-AD (Research Study on Asian Psychotropic Prescription Patterns for Antidepressants) to evaluate the rates and doses of MSs given with ADs and associated factors in 4164 psychiatric patients, using standard bivariate methods followed by multivariable logistic regression modeling. Results Use of MS + AD increased by 104% (5.5% to 11.2%) between 2004 and 2013 and was much more associated with diagnosis of bipolar disorder than major depression or anxiety disorder, as well as with hospitalization > outpatient care, psychiatric > general-medical programs, and young age (all P < 0.001), but not with country, sex, or AD dose. Conclusions The findings provide a broad picture of contemporary use of MSs with ADs in Asia, support predictions that such treatment increased in recent years, and was associated with diagnosis of bipolar disorder, treatment in inpatient and psychiatric settings, and younger age.

KeywordAntidepressant Anxiety Bipolar Disorder Major Depression Mood Stabilizer
DOI10.1097/JCP.0000000000000670
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy ; Psychiatry
WOS SubjectPharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000396116100023
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Singapore Institute of Mental Health
2.National University of Singapore
3.Pushpagiri Medical College
4.Association for the Improvement of Mental Health Programmes
5.McLean Hospital
6.Kuala Lumpur Hospital
7.Harvard Medical School
8.Taipei City Hospital Taiwan
9.Korea University
10.Universitas Airlangga
11.Chang Gung University
12.Chinese University of Hong Kong
13.Chhatrapati Shahuji Maharaj Medical University
14.Taipei Medical University
15.Kyushu University
16.Ministry of Health of People's Republic of China
17.Shanghai Mental Health Center
18.Postgraduate Institute of Medical Education and Research
19.Kobe University School of Medicine
20.Hasanuddin University
21.Prince of Songkla University
22.Universidade de Macau
Recommended Citation
GB/T 7714
Rajaratnam K.,Xiang Y.-T.,Tripathi A.,et al. Clinical use of mood stabilizers with antidepressants in Asia: Report from the research on asian psychotropic prescription patterns for antidepressants (REAP-AD) projects in 2004 and 2013[J]. Journal of Clinical Psychopharmacology,2017,37(2):255-259.
APA Rajaratnam K..,Xiang Y.-T..,Tripathi A..,Chiu H.F.K..,Si T.-M..,...&Sim K..(2017).Clinical use of mood stabilizers with antidepressants in Asia: Report from the research on asian psychotropic prescription patterns for antidepressants (REAP-AD) projects in 2004 and 2013.Journal of Clinical Psychopharmacology,37(2),255-259.
MLA Rajaratnam K.,et al."Clinical use of mood stabilizers with antidepressants in Asia: Report from the research on asian psychotropic prescription patterns for antidepressants (REAP-AD) projects in 2004 and 2013".Journal of Clinical Psychopharmacology 37.2(2017):255-259.
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