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Clozapine augmentation with antiepileptic drugs for treatment-resistant schizophrenia: A meta-analysis of randomized controlled trials
Zheng W.3; Xiang Y.-T.6; Yang X.-H.3; Xiang Y.-Q.1; De Leon J.5
2017-05-01
Source PublicationJournal of Clinical Psychiatry
ISSN01606689
Volume78Issue:5Pages:e498-e505
Abstract

Objective: To meta-analyze randomized controlled trials (RCTs) for the efficacy and safety of adjunctive antiepileptic drugs (AEDs) to augment clozapine therapy for treatment-resistant schizophrenia. Data Sources: The search included databases in English (PubMed, PsycINFO, Embase, and Cochrane Library databases and the Cochrane Controlled Trials Register) and in Chinese (China Journal Net [CJN], WanFang, and China Biology Medicine [CBM]) and references from retrieved articles. The databases were searched using dates inclusive from their onset until January 1, 2016, for terms reflecting (a) schizophrenia, (b) clozapine, and (c) adjunctive drugs. Study Selection: From 1,969 potentially relevant articles, 21 articles describing 22 RCTs were selected. Data Extraction: Two independent investigators extracted data for a random-effects meta-analysis and assessed the quality of the studies using risk of bias and the Jadad scale. Standard mean difference, risk ratio (RR) ±} 95% confidence intervals (CIs), and the number needed to harm (NNH) were used. Results: A total of 22 RCTs (N = 1,227) with 4 AEDs (topiramate [5 RCTs, n = 270], lamotrigine [8 RCTs, n = 299], sodium valproate [6 RCTs, n = 430], and magnesium valproate [3 RCTs, n = 228]) were analyzed. The means weighted by sample size were 12.1 weeks for treatment duration, 36.2 years for age, and 61% for male frequency. Significant superiority in total psychopathology was observed for topiramate (P < .0001), lamotrigine (P = .05), and sodium valproate (P = .002), compared to clozapine monotherapy. After removing outliers, the positive effect of sodium valproate remained, but the positive effect of lamotrigine disappeared (P = .40). Significantly improved efficacy in positive and general symptom severity was observed for topiramate (P = .04 and P = .02, respectively) and sodium valproate (P = .009 and P = .003, respectively). There were no significant differences regarding adverse drug reactions and all-cause discontinuations except for topiramate, which was associated with more all-cause discontinuations (RR = 1.99; 95% CI, 1.16 to 3.39; P = .01; I2 = 0%; NNH = 7). Conclusions: Sodium valproate augmentation was efficacious and safe. Topiramate augmentation had a too-high discontinuation rate. High-quality RCTs are needed to inform clinical recommendations.

DOI10.4088/JCP.16r10782
URLView the original
Indexed BySCI
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry
WOS IDWOS:000410082300004
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Beijing An Ding Hospital, Capital Medical University
2.Universidad de Granada
3.Guangzhou Medical University
4.Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, Campus Alava
5.Eastern State Hospital
6.Universidade de Macau
Recommended Citation
GB/T 7714
Zheng W.,Xiang Y.-T.,Yang X.-H.,et al. Clozapine augmentation with antiepileptic drugs for treatment-resistant schizophrenia: A meta-analysis of randomized controlled trials[J]. Journal of Clinical Psychiatry,2017,78(5):e498-e505.
APA Zheng W.,Xiang Y.-T.,Yang X.-H.,Xiang Y.-Q.,&De Leon J..(2017).Clozapine augmentation with antiepileptic drugs for treatment-resistant schizophrenia: A meta-analysis of randomized controlled trials.Journal of Clinical Psychiatry,78(5),e498-e505.
MLA Zheng W.,et al."Clozapine augmentation with antiepileptic drugs for treatment-resistant schizophrenia: A meta-analysis of randomized controlled trials".Journal of Clinical Psychiatry 78.5(2017):e498-e505.
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