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The association between urinary alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: A controlled pilot study
Zhang Q.-E.1; Ling S.1; Li P.1; Zhang S.1; Ng C.H.2; Ungvari G.S.4; Wang L.-J.3; Lee S.-Y.5; Wang G.1; Xiang Y.-T.5
2018-08-10
Source PublicationInternational Journal of Biological Sciences
ISSN14492288
Volume14Issue:11Pages:1497-1502
AbstractAccumulation of tau protein is associated with both Alzheimer’s disease (AD) and late-life depression (LLD). Alzheimer-associated neuronal thread protein (AD7c-NTP), which is closely linked with the tau protein, is elevated in the cerebrospinal fluid and urine of AD patients. This study examined the association between urinary AD7c-NTP and late-life depression with cognitive impairment. One hundred and thirty-eight subjects were recruited into late-life depression with cognitive impairment (LLD-CI, n=52), late-life depression without cognitive impairment (LLD-NCI, n=29), AD (n=27), and healthy control (HC, n=30) groups. The level of urinary AD7c-NTP was measured using the enzyme-linked immunosorbent assay method. The Montreal Cognitive Assessment scale (MoCA), Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HAMA) were used to assess cognitive functions and depressive and anxiety symptoms in the AD and LLD groups. Urinary levels of AD7c-NTP in the LLD-CI group (1.0±0.7ng/ml) were significantly higher than both the LLD-NCI (0.5±0.3ng/ml) and HC groups (0.5±0.3ng/ml), but lower than in the AD group (1.6±1.7 ng/ml). No significant associations were found in the level of urinary AD7c-NTP in relation to age, gender, education and MoCA in the LLD-CI group. The level of urinary AD7c-NTP appears to be associated with cognitive impairment in late-life depression and may be a potential biomarker for early identification of cognitive impairment in LLD.
KeywordAD7c-NTP Alzheimer’s disease Cognitive impairment Late-life depression
DOI10.7150/ijbs.25000
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Beijing An Ding Hospital, Capital Medical University
2.University of Melbourne
3.Chang Gung University College of Medicine
4.University of Notre Dame Australia
5.Universidade de Macau
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GB/T 7714
Zhang Q.-E.,Ling S.,Li P.,et al. The association between urinary alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: A controlled pilot study[J]. International Journal of Biological Sciences,2018,14(11):1497-1502.
APA Zhang Q.-E..,Ling S..,Li P..,Zhang S..,Ng C.H..,...&Xiang Y.-T..(2018).The association between urinary alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: A controlled pilot study.International Journal of Biological Sciences,14(11),1497-1502.
MLA Zhang Q.-E.,et al."The association between urinary alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: A controlled pilot study".International Journal of Biological Sciences 14.11(2018):1497-1502.
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