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Depressive symptoms in patients with irritable bowel syndrome: A meta-analysis of comparative studies
Zhang Q.-E.1; Wang F.7; Geng Q.6; Zheng W.4; Ng C.H.2; Ungvari G.S.5; Yuan Z.6; Mei S.3; Wang G.1; Xiang Y.-T.6
2018-08-15
Source PublicationInternational Journal of Biological Sciences
ISSN14492288
Volume14Issue:11Pages:1504-1512
AbstractDepression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95%CI: 4.56-18.57, P<0.001; I=76%) and more severe depressive symptoms (n=1,480, SMD=2.02, 95%CI: 1.56-2.48, P<0.001; I=94%). Subgroup analyses revealed that patients with all IBS subtypes had more severe depressive symptoms than controls. In addition, versions of the Hamilton Depression Rating Scale (HAM-D) and IBS diagnostic criteria were significantly associated with depressive symptom severity. Meta-regression analyses revealed that female gender, younger age and small sample size were significantly associated with more severe depressive symptoms. In conclusion, meta-analytic data showed that IBS patients had more frequent and severe depressive symptoms than healthy controls. Adequate screening and treatment for depression should be developed and implemented in this patient population.
KeywordControlled studies Depressive symptoms IBS Meta-analysis
DOI10.7150/ijbs.25001
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Beijing An Ding Hospital, Capital Medical University
2.University of Melbourne
3.Jilin University
4.Guangzhou Medical University
5.University of Notre Dame Australia
6.China-Japan Friendship Hospital
7.Universidade de Macau
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GB/T 7714
Zhang Q.-E.,Wang F.,Geng Q.,et al. Depressive symptoms in patients with irritable bowel syndrome: A meta-analysis of comparative studies[J]. International Journal of Biological Sciences,2018,14(11):1504-1512.
APA Zhang Q.-E..,Wang F..,Geng Q..,Zheng W..,Ng C.H..,...&Xiang Y.-T..(2018).Depressive symptoms in patients with irritable bowel syndrome: A meta-analysis of comparative studies.International Journal of Biological Sciences,14(11),1504-1512.
MLA Zhang Q.-E.,et al."Depressive symptoms in patients with irritable bowel syndrome: A meta-analysis of comparative studies".International Journal of Biological Sciences 14.11(2018):1504-1512.
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