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Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia
Saarelainen T.; Lukkarinen J.A.; Koponen S.; Grohn O.H.J.; Jolkkonen J.; Koponen E.; Haapasalo A.; Alhonen L.; Wong G.; Koistinaho J.; Kauppinen R.A.; Castren E.
2000
Source PublicationMolecular and Cellular Neurosciences
ISSN10447431
Volume16Issue:2Pages:87-96
AbstractIt has been suggested that the increased production of endogenous BDNF after brain insults supports the survival of injured neurons and limits the spread of the damage. In order to test this hypothesis experimentally, we have produced transgenic mouse lines that overexpress the dominant-negative truncated splice variant of BDNF receptor trkB (trkB.T1) in postnatal cortical and hippocampal neurons. When these mice were exposed to transient focal cerebral ischemia by occluding the middle cerebral artery for 45 min and the damage was assessed 24 h later, transgenic mice had a significantly larger damage than wild-type littermates in the cerebral cortex (204 ± 32% of wild-type, P = 0.02), but not in striatum, where the transgene is not expressed. Our results support the notion that endogenously expressed BDNF is neuroprotective and that BDNF signaling may have an important role in preventing brain damage after transient ischemia.
DOI10.1006/mcne.2000.0863
URLView the original
Language英語
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Cited Times [WOS]:70   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationItä-Suomen yliopisto
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GB/T 7714
Saarelainen T.,Lukkarinen J.A.,Koponen S.,et al. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia[J]. Molecular and Cellular Neurosciences,2000,16(2):87-96.
APA Saarelainen T..,Lukkarinen J.A..,Koponen S..,Grohn O.H.J..,Jolkkonen J..,...&Castren E..(2000).Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia.Molecular and Cellular Neurosciences,16(2),87-96.
MLA Saarelainen T.,et al."Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia".Molecular and Cellular Neurosciences 16.2(2000):87-96.
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