UM
Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents
Linden A.-M.1; Vaisanen J.1; Lakso M.1; Nawa H.2; Wong G.1; Castren E.1
2000-06-27
Source PublicationJournal of Molecular Neuroscience
ISSN08958696
Volume14Issue:1-2Pages:27-37
AbstractWe have investigated the potential role of neurotrophic factors in antipsychotic drug action by examining the effects of antipsychotic and psychotropic treatments on the mRNA expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and their receptors, trkB and trkC, respectively, in rat brain. Neither acute nor chronic clozapine treatment significantly affected the expression of these mRNAs in any brain area investigated, except for a decrease in trkB expression in the granule cells of the olfactory bulb. We then examined the effects of the psychotropic agent MK-801. MK-801 (5 mg/kg; 4 h) significantly increased BDNF mRNA in the entorhinal cortex, but did not influence NT-3, trkB, or trkC expression in any brain area except for the olfactory bulb. The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 ± 7% of control) while concomitantly decreasing in the hippocampus (71 ± 2% of control). These data do not support the hypothesis that neurotrophins play an important role in antipsychotic drug action, but rather suggest that induction of BDNF in the entorhinal cortex may play a significant role in the psychotropic action of MK-801.
KeywordBDNF Clozapine Entorhinal cortex Haloperidol MK-801 NT-3 TrkB TrkC
URLView the original
Language英語
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Itä-Suomen yliopisto
2.Niigata University
Recommended Citation
GB/T 7714
Linden A.-M.,Vaisanen J.,Lakso M.,et al. Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents[J]. Journal of Molecular Neuroscience,2000,14(1-2):27-37.
APA Linden A.-M.,Vaisanen J.,Lakso M.,Nawa H.,Wong G.,&Castren E..(2000).Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents.Journal of Molecular Neuroscience,14(1-2),27-37.
MLA Linden A.-M.,et al."Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents".Journal of Molecular Neuroscience 14.1-2(2000):27-37.
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