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Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain
Toronen P.; Storvik M.; Linden A.-M.; Kontkanen O.; Marvanova M.; Lakso M.; Castren E.; Wong G.
2002-10-01
Source PublicationNeurochemical Research
ISSN03643190
Volume27Issue:10Pages:1209-1220
AbstractAgents acting as noncompetitive N-methyl-D-aspartate (NMDA)/glutamate receptor antagonists induce the expression of several genes in limbic cortical regions, such as the cingulate, retrosplenial, and entorhinal cortices. These include important regulatory genes such as the neurotrophin brain-derived neurotrophic factor (BDNF), its receptor trkB, and c-fos. We applied expression profiling methods to find genes coregulated with BDNF following treatment with the prototypical NMDA/glutamate receptor antagonist MK-801. Expression profiling provides a useful technique for describing the molecular and transcriptional level events that follow various processes. We illustrate the utility of microarrays to find novel ESTs regulated by MK-801. We also used expression profiling with microarrays to characterize the levels of transcription factor cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) isoforms that are induced by MK-801. These factors may act as the eventual repressors for BDNF expression via competition and heterodimerization with phosphorylated CREB, a transcription factor important for BDNF expression. Finally, we find and confirm the regulation of Erp29, RTN1, and an ABC transporter by antagonism of NMDA/glutamate receptors as potential stress related molecules in brain. The emerging picture generated by using these expression profiling approaches, identifies several of what likely will be many molecules that take part in the complex events that occur during BDNF signaling mediated by blockade of NMDA/glutamate receptors.
KeywordCAMP Expressed sequence tags Gene expression Kuopiochip Microarray Neurotrophins
DOI10.1023/A:1020985611667
URLView the original
Language英語
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationItä-Suomen yliopisto
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GB/T 7714
Toronen P.,Storvik M.,Linden A.-M.,et al. Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain[J]. Neurochemical Research,2002,27(10):1209-1220.
APA Toronen P..,Storvik M..,Linden A.-M..,Kontkanen O..,Marvanova M..,...&Wong G..(2002).Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain.Neurochemical Research,27(10),1209-1220.
MLA Toronen P.,et al."Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain".Neurochemical Research 27.10(2002):1209-1220.
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