Caenorhabditis elegans models of parkinson’s disease
Wong G.
AbstractThe use of Caenorhabditis elegans as an animal model has its historical roots in the laboratory of Sydney Brenner during the early 1960s. Together with members of his laboratory, which included John Sulston and Robert Horvitz, these pioneers found and exploited the many advantageous features of the nematode as a model system. Initially, the idea was to find a system suitable for studying the fields of development and neuroscience. The model needed to be simple enough to manipulate genetically, yet sufficiently complex to probe deep questions relevant to higher organisms. Later, a few features of the nematode, which now seem obvious in hindsight, proved to be critical. First, the organism was transparent, which was essential to study cell-division, -proliferation, and -death within a living animal. Second, the organism had a reproductive cycle of three days, which allowed for extremely fast and convenient genetic analysis. Third, a point which is often overlooked by the scientific community, is that Sydney Brenner and his early colleagues encouraged a culture of sharing resources and information that has benefited not only the worm research community, but also has served as a model for many later, large scale scientific efforts, including the human genome sequencing project. These efforts culminated in the Nobel prize being awarded to these three early pioneers. Their legacy, however, may be better signified by the enormous collection of worm mutants, clones, sequences, and techniques that are utilized and shared by the worm research community which will be described in the following section.
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Document TypeBook
CollectionUniversity of Macau
AffiliationItä-Suomen yliopisto
Recommended Citation
GB/T 7714
Wong G.. Caenorhabditis elegans models of parkinson’s disease[M],2007.
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